ArticleScientific reports2025
Efficacy and safety of brolucizumab every 6 weeks induction therapy for neovascular age-related macular degeneration.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Disproportionality Analysis of Intravitreal Ranibizumab, Aflibercept, and Brolucizumab for Cardiovascular and Cerebrovascular Events.Journal of clinical pharmacology · 2026Article
- Technologies for Monoclonal Antibody Discovery and Development.International journal of molecular sciences · 2025Review
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Authors and funding
7 authors.
Funding
Abstract
This retrospective study aims to evaluate the short-term efficacy and safety of brolucizumab every 6 weeks induction therapy for neovascular age-related macular degeneration (nAMD) cases. This study included 140 eyes from 140 patients (101 males and 39 females, with a mean age of 77.7 ± 8.7 years) with nAMD who received brolucizumab injections every 6 weeks as part of induction therapy across four participating centers between June 2020 and March 2024. Follow-up lasted for at least 20-24 weeks. Data collected included age, sex, history of nAMD treatment, best-corrected visual acuity (BCVA), central retinal thickness (CRT), presence or absence of exudation, and occurrence of intraocular inflammation (IOI). Sixty-one eyes had prior nAMD treatment. Mean BCVA (logMAR) was 0.40 ± 0.43 before brolucizumab therapy, improving to 0.38 ± 0.42, 0.33 ± 0.41, and 0.34 ± 0.44 after the first, second, and third injections, respectively. Significant improvements in BCVA were observed from the second injection onward (p < 0.05). CRT decreased significantly from baseline of 341.6 ± 151.0 to 219.1 ± 119.8, 204.0 ± 112.9, and 200.8 ± 96.0 after the first, second, and third injections, respectively (p < 1.0 × 10
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