ArticleScientific reports2025
Association between ACTN3 (R577X), BDKRB2 (-9/+9) and AGT (M235T) polymorphisms and physical performance in Brazilian junior handball players.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- The frequency of the ACTN3 polymorphism in Brazil: a systematic review and meta-analysis.BMC medical genomics · 2025Pooled it
Corrections and comments
- Erratum issued
Authors and funding
11 authors.
Funding
Abstract
Team handball performance relies on physical and technical abilities, influenced by environmental and genetic factors. Variants in ACTN3 R577X (rs1815739), BDKRB2 -9/+9 (rs5810761), and AGT Met235Thr (rs699) genes are associated with athletic performance, but their relevance in handball remains unclear. Therefore, this study aimed to investigate the association of these polymorphisms with physical performance in Brazilian junior handball players. The study included 91 junior male handball players (16.4 ± 0.7 years) and 74 age-matched non-athletes. Genotypes for ACTN3 (R577X), BDKRB2 (-9/+9), and AGT (M235T) were identified using PCR-based techniques. Physical tests assessed upper limb strength (medicine ball throw) and lower limb strength (standing long jump). Genotypic and allelic frequencies were compared using Chi-square tests, while performance data were analyzed using ANOVA and t-tests (p ≤ 0.05). No significant differences were found in genotypic or allelic frequencies between athletes and controls for ACTN3 (R577X), BDKRB2 (-9/+9), and AGT (M235T) polymorphisms. Among athletes, ACTN3 RR carriers displayed significantly better upper limb strength (p = 0.049, d = 0.48). However, no genotype significantly influenced lower limb strength or anthropometric traits. Additionally, the study found no significant associations between BDKRB2 and AGT polymorphisms and physical performance parameters. This study demonstrates that specific genetic variants of the ACTN3 (R577X) gene may influence individual traits, such as upper-body strength, in Brazilian junior handball players. However, we found limited influence of BDKRB2 (-9/+9), and AGT (M235T) polymorphisms on overall performance. This lack of association may be attributed to the small sample size and the genetic heterogeneity of the studied population, encouraging further research with larger cohorts.
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