Evidence map›Paper›PMID 39962177›Full record

ArticleNPJ digital medicine2025

Dynamic mortality prediction in critically Ill children during interhospital transports to PICUs using explainable AI.

Zhiqiang Huo, John Booth, Thomas Monks, Philip Knight, Liam Watson, Mark Peters, Christina Pagel, Padmanabhan Ramnarayan, Kezhi Li

Abstract read
In one paragraph

Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhiqiang HuoInstitute of Health Informatics, University College London, London, UK.ORCID http://orcid.org/0000-0001-7705-5331
John BoothDigital Research Innovation and Virtual Environment (DRIVE), Great Ormond Street Hospital, London, UK.
Thomas MonksUniversity of Exeter Medical School, Exeter, UK.
Philip KnightChildren's Acute Transport Service (CATS), Great Ormond Street Hospital, London, UK.
Liam WatsonChildren's Acute Transport Service (CATS), Great Ormond Street Hospital, London, UK.
Mark PetersChildren's Acute Transport Service (CATS), Great Ormond Street Hospital, London, UK.
Christina PagelClinical Operational Research Unit, University College London, London, UK.
Padmanabhan Ramnarayan *Children's Acute Transport Service (CATS), Great Ormond Street Hospital, London, UK.
Kezhi Li *Institute of Health Informatics, University College London, London, UK. ken.li@ucl.ac.uk.ORCID http://orcid.org/0000-0003-3073-3128

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Critically ill children who require inter-hospital transfers to paediatric intensive care units are sicker than other admissions and have higher mortality rates. Current transport practice primarily relies on early clinical assessments within the initial hours of transport. Real-time mortality risk during transport is lacking due to the absence of data-driven assessment tools. Addressing this gap, our research introduces the PROMPT (Patient-centred Real-time Outcome monitoring and Mortality PredicTion), an explainable end-to-end machine learning pipeline to forecast 30-day mortality risks. The PROMPT integrates continuous time-series vital signs and medical records with episode-specific transport data to provide real-time mortality prediction. The results demonstrated that with PROMPT, both the random forest and logistic regression models achieved the best performance with AUROC 0.83 (95% CI: 0.79-0.86) and 0.81 (95% CI: 0.76-0.85), respectively. The proposed model has demonstrated proof-of-principle in predicting mortality risk in transported children and providing individual-level model interpretability during inter-hospital transports.

Identifiers

PMID39962177
PMCPMC11832768

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.