Evidence map›Paper›PMID 39962155›Full record

ArticlePediatric research2025

Neuroprotective effects of vitamin C on hypoxic-ischemic brain injury in neonatal mice.

Kaiyi Liu, Xiaoqing Chen, Fangbing Chen, Wenjuan Dai, Shiyi Zheng, Bi Ze, Wenhao Zhou, Yifeng Lin

Abstract read
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Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kaiyi Liu *Institute of Pediatrics, Children's Hospital, Fudan University, Shanghai, China.
Xiaoqing Chen *Institute of Pediatrics, Children's Hospital, Fudan University, Shanghai, China.
Fangbing ChenInstitute of Pediatrics, Children's Hospital, Fudan University, Shanghai, China.
Wenjuan DaiInstitute of Pediatrics, Children's Hospital, Fudan University, Shanghai, China.
Shiyi ZhengInstitute of Pediatrics, Children's Hospital, Fudan University, Shanghai, China.
Bi ZeInstitute of Pediatrics, Children's Hospital, Fudan University, Shanghai, China.
Wenhao ZhouKey Laboratory of Birth Defects, Children's Hospital, Institutes of Biomedical Sciences, Fudan University, Shanghai, China. zhouwenhao@fudan.edu.cn.
Yifeng LinInstitute of Pediatrics, Children's Hospital, Fudan University, Shanghai, China. irenelin2002@hotmail.com.ORCID http://orcid.org/0000-0003-4411-8388

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHypoxic ischemia (HI) is one of the common causes of neonatal brain injury, leading to neurodevelopmental disorders such as cerebral palsy, epilepsy, and cognitive deficits. In this study, we evaluated neuroprotective effects of vitamin C on the neonatal HI brain injury mouse model.

methodsBrain damage measurement, sensorimotor function in the neonatal period, learning and memory ability in adulthood were carried out in mice treated with vitamin C daily for 7 consecutive days following HI brain injury at postnatal day 7.

resultsVitamin C treatment significantly reduced the hippocampus damage area, infarction volume, hippocampal neuron loss, and suppressed the neuroinflammation after HI injury. Additionally, it improved performance on neonatal sensorimotor function tests and learning and memory ability in adulthood.

conclusionsVitamin C reduced brain injury and improved functional recovery in the neonatal hypoxic ischemia brain damage (HIBD) model. IMPACT: Vitamin C treatment significantly reduced neuron loss and suppressed the neuroinflammation after hypoxic-ischemic brain injury. Vitamin C treatment enhanced sensorimotor functions in neonates and improved cognitive abilities in adults after hypoxic-ischemic brain injury. Vitamin C could be an attractive candidate drug in clinical trials of hypoxic-ischemic encephalopathy therapy.

Indexed as

Ascorbic AcidHypoxia-Ischemia, BrainNeuroprotective AgentsAnimalsAnimals, NewbornCognitionDisease Models, AnimalFemaleHippocampusMaleMemoryMiceMice, Inbred C57BLNeuronsAscorbic AcidNeuroprotective Agents

Identifiers

PMID39962155

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.