Evidence map›Paper›PMID 39962132›Full record

ArticleScientific reports2025

Family history and acquired risk factors for pelvic organ prolapse: a case-control study in Japan.

Asuka Ashikari, Katsumi Kadekawa, Akihiro Tokushige, Hiroyoshi Iwata, Satoko Nagamine, Noriko Machida, Yumi Ikehara, Keiko Mekaru, Junichi Inokuchi, Takeshi Kamiya and 4 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Asuka AshikariDepartment of Urology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Katsumi KadekawaDepartment of Urology, Okinawa Kyodo Hospital, Okinawa, Japan.
Akihiro TokushigeDepartment of Clinical Pharmacology and Therapeutics, University of The Ryukyus, Okinawa, Japan.
Hiroyoshi IwataDepartment of Clinical Pharmacology and Therapeutics, University of The Ryukyus, Okinawa, Japan.
Satoko NagamineDepartment of Systems Physiology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903-0215, Japan.
Noriko MachidaDepartment of Systems Physiology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903-0215, Japan.
Yumi IkeharaDepartment of Clinical Pharmacology and Therapeutics, University of The Ryukyus, Okinawa, Japan.
Keiko MekaruMaternity and Perinatal Care Center, University of the Ryukyus Hospital, Okinawa, Japan.
Junichi InokuchiDepartment of Urology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Takeshi KamiyaDepartment of Orthopedic Surgery, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Kotaro NishidaDepartment of Orthopedic Surgery, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Koshi NakamuraDepartment of Public Health and Epidemiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Shinichiro UedaDepartment of Clinical Pharmacology and Therapeutics, University of The Ryukyus, Okinawa, Japan.
Minoru MiyazatoDepartment of Systems Physiology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903-0215, Japan. miyaz929@med.u-ryukyu.ac.jp.ORCID 0000-0003-3669-4510

Funding

Japan Agency for Medical Research and Development JP22gk021002Japan Society for the Promotion of Science 20K11158
6 · The paper itself

Abstract

This case-control study aimed to investigate the association between family history of pelvic organ prolapse (POP) and its development, combined with known clinical risk factors, in Japanese women. Participants included patients aged ≥ 40 years with and without POP. Self-reported questionnaires assessed delivery methods, disease history, and family history until third-degree relatives. Overall, 305 patients with POP and 338 healthy controls were included. After age-matching, a good balance was achieved between the groups (n = 129 each), with a mean age of 67.7 ± 8.3 years in the POP group and 67.4 ± 8.3 years in the control group. Multivariable logistic regression analysis revealed that the POP group had a significantly higher odds ratio for family history of POP (3.06 [1.09-8.56]; p = 0.03), body mass index (BMI) (1.12 [1.03-1.22]; p = 0.01), and parity (1.51 [1.20-1.89]; p = 0.001). An area under the curve of 0.693 was achieved with a family history of POP, BMI ≥ 23.1 kg/m

Indexed as

Pelvic Organ ProlapseAdultAgedBody Mass IndexCase-Control StudiesFemaleHumansJapanMedical History TakingMiddle AgedParityRisk FactorsSurveys and QuestionnairesBody mass indexFamily historyJapanese Pelvic Floor Distress Inventory (J-PFDI-20)ParityPelvic organ prolapse

Identifiers

PMID39962132
PMCPMC11832764

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.