Evidence map›Paper›PMID 39962094›Full record

ArticleScientific reports2025

PDE4B promotes JNK/NLRP3 activation in the nucleus pulposus and mediates intervertebral disc degeneration.

Weixing Xu, Rana Dhar, Kaiyue Li, Danyang Zheng, Minxin He, Weiguo Ding, Long Xin, Bin Xu, Yuqing He, Qi Peng and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Weixing Xu *Department of Orthopedics, Tongde Hospital of Zhejiang Province, Hangzhou, 310012, Zhejiang, China.
Rana Dhar *Department of Pharmacology, School of Basic Medical Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, China.
Kaiyue Li *Department of Pharmacology, School of Basic Medical Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, China.
Danyang ZhengDepartment of Orthopedics, Tongde Hospital of Zhejiang Province, Hangzhou, 310012, Zhejiang, China.
Minxin HeDepartment of Pharmacology, School of Basic Medical Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, China.
Weiguo DingDepartment of Orthopedics, Tongde Hospital of Zhejiang Province, Hangzhou, 310012, Zhejiang, China.
Long XinDepartment of Orthopedics, Tongde Hospital of Zhejiang Province, Hangzhou, 310012, Zhejiang, China.
Bin XuDepartment of Orthopedics, Tongde Hospital of Zhejiang Province, Hangzhou, 310012, Zhejiang, China.
Yuqing HeDepartment of Pharmacology, School of Basic Medical Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, China.
Qi PengDepartment of Pharmacology, School of Basic Medical Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, China.
Huifang TangDepartment of Pharmacology, School of Basic Medical Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, China. tanghuifang@zju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intervertebral disc degeneration disease (IDD) is one of the leading causes of disability, and current therapies are ineffective. Phosphodiesterase 4B (PDE4B) plays essential roles in regulating the activation of the NLRP3 inflammasome. However, whether PDE4B or NLRP3 is involved in the development of IDD is unclear. This study sought to explore the role of PDE4B in IDD pathogenesis by in vivo and in vitro experiments. This results showed that PDE4B and NLRP3 were significantly upregulated in nucleus pulposus (NP) tissues from IDD-related human patients. Deletion of PDE4B in the NP resulted in downregulated JNK and NLRP3. Aberrant PDE4B expression enhanced the phosphorylation of JNK and NLRP3 expression. Furthermore, genetic ablation of the pde4b gene delayed IDD pathogenesis, and PDE4 inhibitor also can reverse the IDD pathogenesis. Our study showed that aberrant PDE4B activation in NP tissues induces pathological changes in IDD, phosphorylation of JNK and NLRP3 are involved in this process, and inhibition of aberrant PDE4B activity is a potential therapeutic strategy for IDD.

Indexed as

Cyclic Nucleotide Phosphodiesterases, Type 4Intervertebral Disc DegenerationNLR Family, Pyrin Domain-Containing 3 ProteinNucleus PulposusAnimalsFemaleHumansInflammasomesMaleMicePhosphorylationCyclic Nucleotide Phosphodiesterases, Type 4InflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanPDE4B protein, humanIntervertebral disc degeneration diseaseNLRP3Nucleus pulposusPhosphodiesterase 4B

Identifiers

PMID39962094
PMCPMC11833099

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.