Evidence map›Paper›PMID 39961974›Full record

ArticleAnnals of nuclear medicine2025

The prognostic role of staging [18F]PSMA-1007 PET/CT volumetric and dissemination features in prostate cancer.

Domenico Albano, Alessandro Temponi, Francesco Bertagna, Nazareno Suardi, Anna Talin, Marco Lorenzo Bonù, Luca Triggiani

Abstract read
In one paragraph

Article in Annals of nuclear medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Efficacy and safety of [Frontiers in medicine · 2026
    Pooled it
  2. Detection rate of [Frontiers in medicine · 2026
    Pooled it
  3. Pooled it
  4. Head-to-head comparison ofEJNMMI research · 2026
    Article
  5. Article
  6. Prognostic value of lesion dissemination onQuantitative imaging in medicine and surgery · 2026
    Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Domenico AlbanoNuclear Medicine, University of Brescia, Brescia, Italy. doalba87@libero.it.ORCID http://orcid.org/0000-0003-0810-6494
Alessandro TemponiClinical Engineering, ASST Spedali Civili of Brescia, Brescia, Italy.
Francesco BertagnaNuclear Medicine, University of Brescia, Brescia, Italy.
Nazareno SuardiDepartment of Urology, University of Brescia, Brescia, Italy.
Anna TalinNuclear Medicine Department, ASST Spedali Civili di Brescia, Brescia, Italy.
Marco Lorenzo BonùRadiation Oncology, ASST Spedali Civili di Brescia, Brescia, Italy.
Luca TriggianiRadiation Oncology, ASST Spedali Civili di Brescia, Brescia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed the role of volumetric and dissemination features of staging [18F]PSMA-1007 PET/CT in predicting progression-free survival (PFS) in patients with prostate cancer (PCa) and their relationship with the main clinical data (ISUP grade groups, number of lesions, PSA).

methodsWe included 164 patients with high-risk PCa who underwent baseline [18F]PSMA-1007 PET/CT. With the help of LIFEx version 7.7, the main volumetric and dissemination PET parameters were semi-automatically extracted: PSMA-prostate tumor volume (PSMA-TV), PSMA-prostate total lesion (PSMA-TL), PSMA total TV (PSMA-TTV), PSMA total TL (PSMA-TTL) and Dmax corrected for body-surface-area (Dmax

resultsA high correlation was seen between the number of lesions and both PSMA-TTL (r 0.725), and Dmaxbsa (r 0.935). A moderate correlation was registered between PSA and PSMA-TTV (r 0.333), PSMA-TTL (r 0.441), Dmax

conclusionVolumetric and dissemination features derived by staging [18F]PSMA-1007 PET/CT were significantly correlated with PSA and number of lesions. The combination of PSMA-TTL and Dmax

Indexed as

NiacinamideOligopeptidesPositron Emission Tomography Computed TomographyProstatic NeoplasmsAgedAged, 80 and overFluorine RadioisotopesHumansMaleMiddle AgedNeoplasm StagingPrognosisRetrospective StudiesTumor BurdenFluorine-18Fluorine RadioisotopesNiacinamideOligopeptidesPSMA-1007DmaxNuclear medicinePET/CTProstate cancerPSMA

Identifiers

PMID39961974
PMCPMC12014769

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.