Evidence map›Paper›PMID 39961951›Full record

ArticleAIDS and behavior2025

Impact of Depression and HIV Symptoms on Glycemic Outcomes among Patients with HIV and Type 2 Diabetes: A Clinical Cohort Study.

Veronica Joyce Brady, Amanda L Willig, Katerina A Christopoulos, David J Grelotti, George A Yendewa, Conall O'Cleirigh, Richard D Moore, Sonia Napravnik, Allison Webel, Heidi M Crane and 2 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Veronica Joyce BradyDepartment of Research, Cizik School of Nursing, The University of Texas Health Houston, Houston, TX, USA. veronica.j.brady@uth.tmc.edu.ORCID http://orcid.org/0000-0002-9755-3482
Amanda L WilligDivision of Infectious Diseases, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Katerina A ChristopoulosDivision of HIV, ID and Global Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, USA.
David J GrelottiHIV Neurobehavioral Research Program, Department of Psychiatry, University of California San Diego School of Medicine, San Diego, CA, USA.
George A YendewaDepartment of Medicine, Division of Infectious Diseases and HIV Medicine, Case Western Reserve University School of Medicine, Cleveland, USA.
Conall O'CleirighFenway Institute, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Richard D MooreDivisions of Infectious Diseases and General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sonia NapravnikDivision of Infectious Diseases, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Allison WebelSchool of Nursing, University of Washington, Seattle, WA, USA.
Heidi M CraneDivision of Infectious Diseases, School of Medicine, University of Washington, Seattle, WA, USA.
Michael S SaagDivision of Infectious Diseases, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Stephanie A RudermanSchool of Nursing, University of Washington, Seattle, WA, USA.

Funding

Unsolicited R24 for the CFAR-Network of Integrated Clinical Sciences, CNICSR24AI067039 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Michael S. Saag · 2006 to 2026
$99.4M
Center for AIDS Research, University of Alabama at Birmingham 5R24AI067039-18NIAID NIH HHS R24 AI067039
6 · The paper itself

Abstract

Type 2 diabetes (T2DM) and depressive symptoms frequently co-occur among people with HIV (PWH). Depression may impact diabetes management in PWH. This study evaluated the prevalence of concurrent T2DM and depression among PWH and the impact of depression and HIV symptoms on glycemic outcomes (hemoglobin A1c [A1c], blood glucose [BG]) among people with both HIV and T2DM. We conducted a secondary analysis in the CFAR Network of Integrated Clinical Systems, a multisite clinical cohort including a diverse population of PWH in care from July 2005 through July 2023. Linear regression and linear mixed models were used to estimate the association between depression, HIV symptoms, and glycemic outcomes (A1C, BG) at baseline and over time. Of the 18,562 PWH, 2,945 (16%) also had T2DM. PWH with T2DM were older (56 vs. 49 years) and more often non-Hispanic Black and cis-gender men. The prevalence of depression was not significantly different between PWH with or without T2DM (20% vs. 21%) although more PWH with T2DM received antidepressant medications. Among people with both HIV and T2DM, HIV baseline symptoms and depression were not associated with a change in A1c. Increases in time-updated HIV symptom scores were associated with random (non-fasting) BG levels, with each additional HIV symptom resulting in 0.8 mg/dL increase in random BG level (95% CI: 0.04-1.60, p = 0.04). The prevalence of T2DM was higher among PWH than in the general population. Although depression appears to be well managed, other factors impacting glycemic outcomes among people with both HIV and T2DM require further study.

Indexed as

Blood GlucoseDepressionDiabetes Mellitus, Type 2HIV InfectionsAdultCohort StudiesFemaleGlycated HemoglobinHumansMaleMiddle AgedPrevalenceBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanBlood glucoseDepressionHemoglobin A1cHIVType 2 Diabetes mellitus

Identifiers

PMID39961951
PMCPMC12752771

What OpenQuestion holds

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LicenceTDM
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.