ArticleJournal of epidemiology and global health2025
Epidemiological Characteristics and Disease Burden of Tuberculous Meningitis in Hospitalized Children in China: A Nationwide Retrospective Study.
Article in Journal of epidemiology and global health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Unmasking the cognitive burden of adult tuberculous meningitis: A systematic review and meta analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Pooled it
- The epidemiology and disease economic burden of osteoarticular tuberculosis in hospitalized children in China: a nationwide cross-sectional retrospective study.BMC infectious diseases · 2025Article
- The burden of infective encephalitis in children in Asian countries (1990-2021): systematic analysis and projection of the burden of disease.Frontiers in cellular and infection microbiology · 2025Article
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9 authors.
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Abstract
objectivesTo investigate the epidemiological profile and cost burden of pediatric inpatients with tuberculous meningitis (TBM) in China.
methodsWe conducted a descriptive multicenter study involving pediatric TBM inpatients from 9 provincial hospitals and 20 municipal hospitals across 24 provinces in China from January 2016 to December 2021. Sociodemographic and geographic variables, admission and discharge information were extracted from face sheets of discharge medical records to describe the epidemiological characteristics. Length of hospital stay (LOS) and hospitalization expenses were used to assess disease burden.
resultsTBM accounted for 0.01% (971/7,647,598) of total hospitalization cases and 15.82% (971/6,138) of TB cases. The proportion of TBM children aged 1-3 (39.13%, 380/971) years were the highest. TBM children aged < 1 year had longest LOS (12d) and highest total costs ($2447.55). Minority patients had a higher proportion of TBM hospitalizations (24.09% vs 13.79%), longer LOS (11d) and higher diagnostic costs ($745.95 vs $628.47) than Han people. The northwest region had the highest rate of TBM hospitalization (n = 272, 28.01%) and the longest LOS (8d). TBM + PTB group exhibited the highest rate of outpatient admission (78.51%,263/335), shortest LOS (5d) and lowest total cost ($1729.75) and diagnostic cost ($827.30). The most prevalent concomitant TB infection site was the lung (n = 494, 50.82%). TBM + PTB + other EPTB group had the longest LOS (14d) and highest total cost ($3380.54).
conclusionPediatric TBM poses substantial disease burden in China, especially in western regions and children under six years old. Early diagnosis and treatment for children with TBM should be suggested.
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