Evidence map›Paper›PMID 39961943›Full record

ArticleNeuromolecular medicine2025

The Role of Lactic Acid Bacteria in Improving Behavioral Deficits, Serum Levels of Vitamin D3, B12 and Reducing Oxidative Stress and Demyelination in a Cuprizone-induced Demyelination Model of Rat.

Maryam Kazemimiraki, Elham Moazamian, Mohammad Javad Mokhtari, Mehrdad Gholamzad

Abstract read
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In one paragraph

Article in Neuromolecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Maryam KazemimirakiDepartment of Genetics, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran.ORCID https://orcid.org/0009-0005-3150-330X
Elham MoazamianDepartment of Microbiology, Faculty of Sciences, Agriculture and Modern Technology, Shiraz Branch, Islamic Azad University, Shiraz, Iran. elhammoazamian@gmail.com.ORCID https://orcid.org/0000-0002-4445-3971
Mohammad Javad MokhtariDepartment of Biology, Zarghan Branch, Islamic Azad University, Zarghan, Iran.ORCID https://orcid.org/0000-0001-5066-9632
Mehrdad GholamzadDepartment of Microbiology and Immunology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.ORCID https://orcid.org/0000-0003-0626-8481

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis constitutes a chronic, inflammatory, and demyelinating disorder affecting the central nervous system, with an estimated global prevalence of 2.5 million individuals. Emerging research underscores the significant influence of the gut microbiota on the immune system, suggesting a potential role in the initiation and progression of inflammatory diseases. This study investigated the potential therapeutic effects of Lactobacillus and Bifidobacterium species isolated from traditional dairy products on cuprizone-induced demyelination in a rat model. 48 adults male Wistar rats were randomly assigned to six groups. Demyelination was induced by daily oral administration of 0.6% (w/w) cuprizone mixed with food for 30 days. Subsequently, treated groups received oral administration of mixed of Lactiplantibacillus plantarum, Lactobacillus acidophilus, and Lactobacillus reuteri: and mixed of Bifidobacterium bifidum and Bifidobacterium animalis. A control group received no bacteria intervention. Behavioral deficits were assessed using grip-traction, beam-walking, and grid-walking tests. Oxidative stress biomarkers were quantified using colorimetric assays. The extent of demyelination was evaluated by hematoxylin and eosin staining of the corpus callosum. Serum levels of vitamin D

Indexed as

BifidobacteriumCholecalciferolDemyelinating DiseasesLactobacillusOxidative StressProbioticsAnimalsBehavior, AnimalCorpus CallosumCuprizoneDisease Models, AnimalGastrointestinal MicrobiomeMaleRandom AllocationRatsRats, WistarCholecalciferolCuprizoneCuprizoneMotor testsMultiple sclerosisOxidative stressVitamin B12Vitamin D3

Identifiers

PMID39961943

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.