ArticleChirality2025
Exploring Naproxen Cocrystals Through Solid-State Vibrational Circular Dichroism.
Article in Chirality, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The trial behind it
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Who cites it
2 citing papers in PubMed.
- Spectroscopy and Conformer-Selective Photoelectron Circular Dichroism of Chiral Molecules.Chemistry, an Asian journal · 2026Review
- Mixed pain: clinical practice recommendations.Frontiers in medicine · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Vibrational circular dichroism (VCD) spectroscopy appears as a useful method for characterizing optically active substances in the solid state. This is particularly important for active pharmaceutical ingredients. However, measurement and interpretation of the spectra bring about many difficulties. To assess the experimental and computational methodologies, we explore an anti-inflammatory drug, naproxen. Infrared (IR) and VCD spectra of the pure compound and its cocrystals with alanine and proline were recorded, and the data were interpreted by quantum chemical simulations based on a cluster model and density functional theory. Although unpolarized IR spectroscopy can already distinguish pure ingredients from cocrystals or a mixture, the VCD technique is much more sensitive. For example, the naproxen carboxyl group strongly interacts with the zwitterionic alanine in the cocrystal via two strong hydrogen bonds, which results in a rather rigid structure crystallizing in the chiral P2
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