Evidence map›Paper›PMID 39961201›Full record

ArticleDevelopmental cognitive neuroscience2025

Maternal depressive symptoms in childhood and offspring brain cortical and subcortical volumetric change: A repeated imaging study from age 4-10 years.

Yuna Koyama, Ai Peng Tan, Ekaterina Sadikova, Peipei Setoh, Birit Broekman, Juan Helen Zhou, Peter Gluckman, Helen Chen, Henning Tiemeier

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cognitive neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors.

Yuna KoyamaDepartment of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Diagnostic Imaging, National University Hospital Singapore, Singapore 119074, Singapore; Department of Public Health, Institute of Science Tokyo, Tokyo 113-8510, Japan. Electronic address: ykoyama@hsph.harvard.edu.
Ai Peng TanDepartment of Diagnostic Imaging, National University Hospital Singapore, Singapore 119074, Singapore; Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A⁎STAR), Singapore 138632, Singapore; Department of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Ekaterina SadikovaDepartment of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Peipei SetohPsychology Division, School of Social Sciences, Nanyang Technological University, Singapore 639818, Singapore.
Birit BroekmanSingapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A⁎STAR), Singapore 138632, Singapore; Department of Psychiatry, Amsterdam UMC, location VUmc, VU University, Amsterdam 1076, the Netherlands; Department of Psychiatry, Onze Lieve Vrouwe Gasthuis, Amsterdam 1061, the Netherlands.
Juan Helen ZhouCentre for Sleep and Cognition, Centre for Translational Magnetic Resonance Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117549, Singapore; Human Potential Translational Research Program, Department of Medicine, National University of Singapore, Singapore 117597, Singapore; Department of Electrical and Computer Engineering, Integrative Science and Engineering Programme (ISEP), NUS Graduate School, National University of Singapore, Singapore 119077, Singapore.
Peter GluckmanInternational Science Council, Paris 75116, France; Koi Tu: The Centre for Informed Futures, University of Auckland, Auckland 1010, New Zealand.
Helen ChenDepartment of Psychological Medicine, KK Women's and Children's Hospital, Singapore 229899, Singapore; Duke-National University of Singapore, Singapore 118420, Singapore.
Henning TiemeierDepartment of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.

Funding

The Training Program in Reproductive, Perinatal, and Pediatric Life Course EpidemiologyT32HD104612 · NICHD · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Sonia Hernandez-Diaz, Henning Tiemeier · 2021 to 2026
$2.2M
NICHD NIH HHS T32 HD104612
6 · The paper itself

Abstract

Maternal depressive symptoms have been associated with offspring's brain structural differences. However, previous studies were limited by cross-sectional designs, brain region-of-interest analyses, or clinical samples. Importantly, few studies assessed the early childhood brain. This study analyzed data from a Singaporean cohort of 217 children with 589 repeated structural neuroimaging from 4.5 to 10.5 years (2-4 assessments) in relation to maternal depressive symptoms. Maternal depressive symptoms were measured by questionnaire at child age 4.5 years. Mixed models explored within-sample change accounting for non-linear brain development. Multiple testing was corrected, and a stringent threshold was applied. Maternal depressive symptoms were associated with persistently smaller precentral gyral volume over time (β = -0.162 [-0.238; -0.086], p

Indexed as

BrainCerebral CortexChild DevelopmentChild of Impaired ParentsDepressionMothersAdultChildChild, PreschoolFemaleHumansMagnetic Resonance ImagingMaleNeuroimagingSingaporeBrain volumetric developmentDelayed developmentDeprivationMaternal depressionRepeated brain imagingStructural MRI

Identifiers

PMID39961201
PMCPMC11872126

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.