ArticleNeurology2025
Quantifying Brain Health in Acute Ischemic Stroke Through Effective Reserve.
Article in Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- A composite measure of cerebral small vessel disease predicts cognitive change after stroke.medRxiv : the preprint server for health sciences · 2026Article
- Brain Health Loss Mediates the Effect of Infarct Volume on Functional Outcome in Ischemic Stroke.medRxiv : the preprint server for health sciences · 2025Article
- Magnetic Resonance Imaging Markers of Brain Health Improve Assessment of Functional Outcome After Acute Ischemic Stroke: A Quantitative Comparison Study.medRxiv : the preprint server for health sciences · 2025Article
- Brain volume is a better biomarker of outcomes in ischemic stroke compared to brain atrophy.Frontiers in stroke · 2024Article
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4 authors.
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Abstract
objectiveTo quantify brain health using a measure of reserve that incorporates pre-existing pathology.
methodsWe analyzed 2 retrospective ischemic stroke cohorts (GASROS and SALVO) with neuroimaging and 90-day modified Rankin Scores (mRS) available. White matter hyperintensity (WMHv), brain, and intracranial volumes were automatically extracted and brain parenchymal fraction (BPF) calculated. The latent variable effective reserve (eR) was modeled using age, WMHv, and BPF or brain volume in GASROS. Models were compared using Bayes Information Criterion (BIC). The best model's eR estimates were categorized into quartiles and evaluated in SALVO.
resultsGASROS included 476 (median age: 65.8; 65.3% male) and SALVO included 43 (median age: 69.2; 62.8% male) patients. Inverse associations between eR and mRS was seen in both models, with brain volume outperforming BPF (path coefficients: -0.67, -0.48, respectively; DISCUSSION: Expanding the concept of eR, highlights its clinical translational potential. The strong link between higher eR and better outcomes underscores its value as a protective brain health metric.
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