Evidence map›Paper›PMID 39960781›Full record

ArticleThe FEBS journal2025

Hydromethylthionine sustains truncated tau-dependent inflammation-lowering effects in mouse brain.

Renato X Santos, Sophie H Lee, Richard Lofthouse, Valeria Melis, Lianne Robinson, Michael Leith, Eline Dreesen, Paul Armstrong, Thomas Vorley, Elizabeth A Goatman and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The FEBS journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Renato X SantosInstitute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, UK.ORCID 0000-0003-3737-8296
Sophie H LeeInstitute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, UK.
Richard LofthouseInstitute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, UK.
Valeria MelisInstitute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, UK.
Lianne RobinsonInstitute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, UK.
Michael LeithDepartment of Chemistry, School of Natural and Computing Sciences, University of Aberdeen, UK.
Eline DreesenInstitute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, UK.
Paul ArmstrongInstitute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, UK.
Thomas VorleyInstitute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, UK.
Elizabeth A GoatmanInstitute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, UK.
Claire HullTauRx Therapeutics Ltd., Aberdeen, UK.
Gernot RiedelInstitute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, UK.
Claude M WischikInstitute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, UK.
Charles R HarringtonInstitute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, UK.ORCID 0000-0003-2250-3920

Funding

Wista Laboratories Ltd., Singapore PAR1577
6 · The paper itself

Abstract

Tauopathies are a heterogeneous mixture of neurodegenerative disorders, including Alzheimer's disease and frontotemporal dementia (FTD), characterised by the accumulation of tau filaments in brain tissue. Tau protein aggregation is inhibited by hydromethylthionine (HMT), an effect that appeared to be prevented in clinical trials for subjects already receiving acetylcholinesterase inhibitors or memantine. Since neuroinflammatory responses are associated with tauopathies, we investigated the effect of HMT on the brain immune response and inflammatory status in line 66 (L66) mice, an FTD-like model overexpressing human tau, in the presence of memantine. We determined whether HMT (5 and 15 mg·kg

Indexed as

BrainFrontotemporal DementiaInflammationTauopathiestau ProteinsAnimalsDisease Models, AnimalHumansMaleMemantineMiceMice, TransgenicMicrogliaTumor Necrosis Factor-alphaMapt protein, mouseMemantinetau ProteinsTumor Necrosis Factor-alphaAlzheimer's diseasefrontotemporal dementiahydromethylthionineneuroinflammationTau protein

Identifiers

PMID39960781
PMCPMC12103070

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.