Evidence map›Paper›PMID 39960649›Full record

ArticleEuropean journal of nutrition2025

Association between ultra-processed food consumption and inflammation: insights from the STANISLAS cohort.

Lea Lin Chun Hu Xia, Nicolas Girerd, Zohra Lamiral, Kevin Duarte, Ludovic Merckle, Celine Leroy, Julie-Anne Nazare, Laurie Van Den Berghe, Louise Seconda, Axelle Hoge and 5 more

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Article in European journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lea Lin Chun Hu XiaCentre d'Investigation Clinique-Plurithématique, Inserm CIC-P 1433, Pierre Drouin, INSERM, CHRU de Nancy Brabois, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Institut Lorrain du Coeur Et Des Vaisseaux Louis Mathieu, Université de Lorraine, 4 Rue du Morvan, 54500, Vandoeuvre-Lès-Nancy, France.
Nicolas GirerdCentre d'Investigation Clinique-Plurithématique, Inserm CIC-P 1433, Pierre Drouin, INSERM, CHRU de Nancy Brabois, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Institut Lorrain du Coeur Et Des Vaisseaux Louis Mathieu, Université de Lorraine, 4 Rue du Morvan, 54500, Vandoeuvre-Lès-Nancy, France. n.girerd@chru-nancy.fr.
Zohra LamiralCentre d'Investigation Clinique-Plurithématique, Inserm CIC-P 1433, Pierre Drouin, INSERM, CHRU de Nancy Brabois, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Institut Lorrain du Coeur Et Des Vaisseaux Louis Mathieu, Université de Lorraine, 4 Rue du Morvan, 54500, Vandoeuvre-Lès-Nancy, France.
Kevin DuarteCentre d'Investigation Clinique-Plurithématique, Inserm CIC-P 1433, Pierre Drouin, INSERM, CHRU de Nancy Brabois, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Institut Lorrain du Coeur Et Des Vaisseaux Louis Mathieu, Université de Lorraine, 4 Rue du Morvan, 54500, Vandoeuvre-Lès-Nancy, France.
Ludovic MerckleCentre d'Investigation Clinique-Plurithématique, Inserm CIC-P 1433, Pierre Drouin, INSERM, CHRU de Nancy Brabois, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Institut Lorrain du Coeur Et Des Vaisseaux Louis Mathieu, Université de Lorraine, 4 Rue du Morvan, 54500, Vandoeuvre-Lès-Nancy, France.
Celine LeroyCentre d'Investigation Clinique-Plurithématique, Inserm CIC-P 1433, Pierre Drouin, INSERM, CHRU de Nancy Brabois, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Institut Lorrain du Coeur Et Des Vaisseaux Louis Mathieu, Université de Lorraine, 4 Rue du Morvan, 54500, Vandoeuvre-Lès-Nancy, France.
Julie-Anne NazareCentre de Recherche en Nutrition Humaine Rhône-Alpes, Hospices Civils de Lyon, F-CRIN/FORCE Network, Univ-Lyon, CarMeN Laboratory, Université Claude Bernard Lyon1, Lyon, France.
Laurie Van Den BergheCentre de Recherche en Nutrition Humaine Rhône-Alpes, Hospices Civils de Lyon, F-CRIN/FORCE Network, Univ-Lyon, CarMeN Laboratory, Université Claude Bernard Lyon1, Lyon, France.
Louise SecondaCentre de Recherche en Nutrition Humaine Rhône-Alpes, Hospices Civils de Lyon, F-CRIN/FORCE Network, Univ-Lyon, CarMeN Laboratory, Université Claude Bernard Lyon1, Lyon, France.
Axelle HogeDépartement Des Sciences de La Santé Publique, Université de Liège, Liège, Belgium.
Michèle GuillaumeDépartement Des Sciences de La Santé Publique, Université de Liège, Liège, Belgium.
Martine LavilleCentre de Recherche en Nutrition Humaine Rhône-Alpes, Hospices Civils de Lyon, F-CRIN/FORCE Network, Univ-Lyon, CarMeN Laboratory, Université Claude Bernard Lyon1, Lyon, France.
Patrick RossignolCentre d'Investigation Clinique-Plurithématique, Inserm CIC-P 1433, Pierre Drouin, INSERM, CHRU de Nancy Brabois, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Institut Lorrain du Coeur Et Des Vaisseaux Louis Mathieu, Université de Lorraine, 4 Rue du Morvan, 54500, Vandoeuvre-Lès-Nancy, France.
Jean-Marc BoivinCentre d'Investigation Clinique-Plurithématique, Inserm CIC-P 1433, Pierre Drouin, INSERM, CHRU de Nancy Brabois, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Institut Lorrain du Coeur Et Des Vaisseaux Louis Mathieu, Université de Lorraine, 4 Rue du Morvan, 54500, Vandoeuvre-Lès-Nancy, France.
Sandra WagnerCentre d'Investigation Clinique-Plurithématique, Inserm CIC-P 1433, Pierre Drouin, INSERM, CHRU de Nancy Brabois, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Institut Lorrain du Coeur Et Des Vaisseaux Louis Mathieu, Université de Lorraine, 4 Rue du Morvan, 54500, Vandoeuvre-Lès-Nancy, France.ORCID http://orcid.org/0000-0002-3251-3754

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeHigh consumption of ultra-processed food (UPF) is associated with an increased risk of developing chronic diseases. Inflammation may be one of the underlying mechanisms behind this association. However, only a limited number of studies have investigated the association between UPF consumption and a few selected inflammation biomarkers, yielding inconsistent results. This study aimed to assess the cross-sectional association between UPF consumption (as a whole and 10 sub-categories), and 78 circulating proteins related to inflammation.

methodsThe present study included 1594 adult participants from the STANISLAS cohort. UPF consumption was estimated using the NOVA classification, and linear regression models were used to assess their association with circulating proteins.

resultsUPFs accounted for 28% of the total energy intake and 5.7 servings on average per day. In the unadjusted model, 15 circulating proteins had a significant association with UPF consumption. After adjustment, only (FGF-19) was significantly associated with UPF consumption (β =  - 0.02[- 0.03; - 0.003]).

conclusionUPF consumption was negatively associated with Fibroblast Growth Factor 19 (FGF-19) serum levels. When considering UPF sub-categories, no circulating proteins were associated with dairy products and dairy desserts. Of note, circulating proteins were differentially associated depending on the sub-category of UPF. Further studies are needed to better understand the link between UPF and inflammation.

Indexed as

DietFast FoodsInflammationAdultBiomarkersCohort StudiesCross-Sectional StudiesEnergy IntakeFemaleFood, ProcessedHumansMaleMiddle AgedBiomarkersCirculating proteinFibroblast growth factor 19InflammationNOVAOlinkUltra-processed food

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.