ArticleImmunologic research2025
Risk factors for predicting medium-giant coronary artery aneurysms in Kawasaki disease.
Article in Immunologic research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- An interpretable machine learning model for early risk stratification of medium-to-giant coronary artery aneurysm in Kawasaki disease: development and external validation.Pediatric research · 2026Article
- Development and validation of an interpretable machine learning model for predicting medium-to-giant coronary aneurysms in Kawasaki disease.Frontiers in immunology · 2026Article
- An integrated and interpretable machine learning framework for Kawasaki disease diagnosis and risk prediction.Translational pediatrics · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
The objective of this study is to determine whether the data of blood profiles before and after therapy can be useful for predicting medium-giant coronary artery aneurysms (CAA) in patients with KD. In total, 1856 KD children from 2013 to 2022 were prospectively recruited. Serial blood samples on the day of initial IVIG infusion and 36-48 h thereafter were collected. The clinical and laboratory parameters were compared between the medium-giant CAA (n = 95) group and the non-CAA group (n = 1761). Multivariate analysis was performed to explore the independent risk factors for medium-giant CAA and the receiver operating characteristic (ROC) curve was used to evaluate and assess the prediction validities. Fever duration prior to initial IVIG infusion, IVIG resistance, cardiac enlargement, white blood cells prior to initial IVIG treatment, albumin levels, and the percentage of △neutrophils were independent risk factors for predicting medium-giant CAA. The predictive value of △neutrophil percentage (≤ 30.2%) demonstrates a relatively high sensitivity (0.84) and a moderate specificity (0.52) for predicting acute medium-giant CAA. The △neutrophil percentage before and 36-48 h after initial IVIG infusion might serve as a promising biomarker in the prediction of medium-giant CAA for KD patients.
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Registered trials
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