Evidence map›Paper›PMID 39960413›Full record

ArticleOncoimmunology2025

Patient-derived tumor explant models of tumor immune microenvironment reveal distinct and reproducible immunotherapy responses.

Rita Turpin, Karita Peltonen, Jenna H Rannikko, Ruixian Liu, Anita N Kumari, Daniel Nicorici, Moon Hee Lee, Minna Mutka, Panu E Kovanen, Laura Niinikoski and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncoimmunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Article
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  4. Review
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Rita TurpinCancer Cell Circuitry Laboratory, Translational Cancer Medicine, Medical Faculty, University of Helsinki, Helsinki, Finland.
Karita PeltonenHematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.
Jenna H RannikkoMediCity Research Laboratory and InFLAMES Flagship, University of Turku, Turku, Finland.
Ruixian LiuCancer Cell Circuitry Laboratory, Translational Cancer Medicine, Medical Faculty, University of Helsinki, Helsinki, Finland.
Anita N KumariHematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.
Daniel NicoriciCancer Cell Circuitry Laboratory, Translational Cancer Medicine, Medical Faculty, University of Helsinki, Helsinki, Finland.
Moon Hee LeeHematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.
Minna MutkaDepartment of Pathology, HUSLAB and Haartman Institute, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.
Panu E KovanenDepartment of Pathology, HUSLAB and Haartman Institute, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.
Laura NiinikoskiDivision of Breast Surgery, Comprehensive Cancer Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Tuomo MeretojaDivision of Breast Surgery, Comprehensive Cancer Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Johanna MattsonComprehensive Cancer Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Petrus JärvinenAbdominal Center, Urology, Helsinki University and Helsinki University Hospital, Helsinki, Finland.
Kanerva LahdensuoAbdominal Center, Urology, Helsinki University and Helsinki University Hospital, Helsinki, Finland.
Riikka JärvinenAbdominal Center, Urology, Helsinki University and Helsinki University Hospital, Helsinki, Finland.
Sara TornbergAbdominal Center, Urology, Helsinki University and Helsinki University Hospital, Helsinki, Finland.
Tuomas MirttiDepartment of Pathology, Helsinki University Hospital and Research Program in Systems Oncology, University of Helsinki, Helsinki, Finland.
Pia BoströmDepartment of Pathology, Turku University Hospital, Turku, Finland.
Ilkka KoskivuoDepartment of Digestive Surgery and Urology, Turku University Hospital and University of Turku, Turku, Finland.
Anil ThotakuraImmuno-Oncology, Oncology Research, Orion Corporation, Turku, Finland.
Jeroen PouwelsCancer Cell Circuitry Laboratory, Translational Cancer Medicine, Medical Faculty, University of Helsinki, Helsinki, Finland.
Maija HollménMediCity Research Laboratory and InFLAMES Flagship, University of Turku, Turku, Finland.
Satu MustjokiHematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.
Juha KlefströmCancer Cell Circuitry Laboratory, Translational Cancer Medicine, Medical Faculty, University of Helsinki, Helsinki, Finland.ORCID 0000-0001-7124-8431

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor-resident immune cells play a crucial role in eliciting anti-tumor immunity and immunomodulatory drug responses, yet these functions have been difficult to study without tractable models of the tumor immune microenvironment (TIME). Patient-derived

Indexed as

Breast NeoplasmsCarcinoma, Renal CellImmunotherapyKidney NeoplasmsTumor MicroenvironmentCytokinesFemaleHumansImmunity, InnateReproducibility of ResultsCytokinesBreast cancerex vivo modelimmune checkpointIO-treatmentpatient-derived explantsrenal cell carcinomatumor immune microenvironment

Identifiers

PMID39960413
PMCPMC11834457

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.