Evidence map›Paper›PMID 39960341›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Staphylococcus Aureus Tames Nociceptive Neurons to Suppress Synovial Macrophage Responses for Sustained Infection in Septic Arthritis.

Xinyu Fang, Yang Chen, Haiqi Ding, Changyu Huang, Hongxin Hu, Chaofan Zhang, Yunzhi Lin, Qijin Wang, Xueni Hu, Yiming Lin and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Xinyu FangDepartment of Orthopedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350000, China.
Yang ChenDepartment of Orthopedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350000, China.
Haiqi DingDepartment of Orthopedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350000, China.
Changyu HuangDepartment of Orthopedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350000, China.
Hongxin HuDepartment of Orthopedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350000, China.
Chaofan ZhangDepartment of Orthopedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350000, China.
Yunzhi LinDepartment of Stomatology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350000, China.
Qijin WangDepartment of Orthopedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350000, China.
Xueni HuDepartment of Laboratory Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350000, China.
Yiming LinDepartment of Orthopedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350000, China.
Yongfa ChenDepartment of Orthopedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350000, China.
Nanxin ZhangDepartment of Orthopedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350000, China.
Xuhui YuanDepartment of Orthopedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350000, China.
Ying HuangDepartment of Orthopedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350000, China.
Wenbo LiDepartment of Orthopedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350000, China.
Susheng NiuKey Laboratory of Orthopedics & Traumatology of Traditional Chinese Medicine and Rehabilitation Ministry of Education, Fujian University of Traditional Chinese Medicine, Fuzhou, 350000, China.
Jianhua LinDepartment of Orthopedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350000, China.
Bin YangDepartment of Laboratory Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350000, China.
Tifei YuanShanghai Key Laboratory of Psychotic Disorders, Brain Health Institute, National Center for Mental Disorders, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine and School of Psychology, Shanghai, 200000, China.
Wenming ZhangDepartment of Orthopedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350000, China.ORCID https://orcid.org/0000-0003-1567-7279

Funding

Fujian Province Health Technology Project 2024QNA029National Natural Science Foundation of China 82171370National Natural Science Foundation of China 82272510Natural Science Foundation of Fujian Province 2022J01219Natural Science Foundation of Fujian Province 2024J01225
6 · The paper itself

Abstract

The interaction between the nervous system and immune system during chronic bacterial infection remains unclear. Here, it is reported that Staphylococcus aureus (S. aureus) infection induces calcitonin gene-related peptide (CGRP) secretion from intra-articular transient receptor potential cation channel subfamily V member 1 positive (TRPV1

Indexed as

Arthritis, InfectiousMacrophagesNociceptorsStaphylococcal InfectionsStaphylococcus aureusSynovial MembraneAnimalsCalcitonin Gene-Related PeptideMaleMiceMice, Inbred C57BLCalcitonin Gene-Related Peptidecalcitonin gene‐related peptidechronic septic arthritismacrophagesnociceptive neuronStaphylococcus aureus

Identifiers

PMID39960341
PMCPMC11984863

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.