ArticleJournal of cachexia, sarcopenia and muscle2025
Sarcopenia and Insulin Resistance Collective Effect on Atrial Fibrillation Risk: A Non-Diabetic Elderly Cohort Study.
Article in Journal of cachexia, sarcopenia and muscle, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between sarcopenia and atrial fibrillation: a meta-analysis.Frontiers in medicine · 2026Pooled it
- Lipoprotein(a) and atherosclerosis risk across estimated glucose disposal rate strata: evaluating synergistic predictive utility.Lipids in health and disease · 2026Article
- Collective exerkines mediate physical activity mitigating new-onset heart failure risk in older adults with prediabetes or diabetes: a community-based longitudinal cohort study.Cardiovascular diabetology · 2026Article
- Cumulative exposure to the estimated glucose disposal rate and incident stroke in individuals with cardiovascular-kidney-metabolic syndrome stages 0-4: 6-year longitudinal evidence from CHARLS.Cardiovascular diabetology · 2026Article
- Association between estimated glucose disposal rate and metabolic syndrome in older adults with sarcopenia.Frontiers in nutrition · 2026Article
- Sarcopenia in atrial fibrillation: a prospective study.Turkish journal of medical sciences · 2026Article
- Combined effect of skeletal muscle mass loss and elevated insulin resistance on heart failure risk in older adults: a community-based longitudinal cohort study.Cardiovascular diabetology · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundAppendicular skeletal muscle mass index (ASMI), a crucial indicator of sarcopenia and estimated glucose disposal rate (eGDR), a surrogate marker of insulin resistance (IR), are associated with the risk of cardiovascular diseases. However, it remains unclear whether the collective effects, including the impact of the temporal progression of ASMI and eGDR, affect atrial fibrillation (AF) risk. This study aims to elucidate the association between the collective effects of ASMI and eGDR and AF risk in the non-diabetic older population.
methodsA total of 8060 non-diabetic older individuals from a community-based cohort study were used to prospectively analyse the association between the collective effects of baseline ASMI and eGDR and AF risk. Among them, 7651 were eligible and used for dual-trajectory analysis of the association between dual trajectory of ASMI and eGDR and AF risk. The temporal development of ASMI and eGDR over time was determined using a dual-trajectory model. Statistical analyses involved restricted cubic splines and Fine-Gray competing risk models, adjusting for potential confounders.
resultsIn the prospective analysis, the hazard ratio (HR) of AF was 1.762 (95% confidence interval [CI]: 1.528-2.032) in the low ASMI group compared to the normal ASMI group in total participants. Restricted cubic splines analysis demonstrated L-shaped associations between AF risk and ASMI and eGDR, with inflection points at 7.23 kg/m
conclusionsThe collective effects of ASMI and eGDR are significantly associated with AF risk in the non-diabetic older population. Collective management of skeletal muscle mass and IR might be a useful and effective management strategy for preventing and controlling AF.
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