Evidence map›Paper›PMID 39959779›Full record

ArticleHeliyon2024

Vitamin D injection into the dorsal-CA1 hippocampus improves short-term sleep deprivation induced cognitive impairment in male rats.

Amir Rezagholizadeh, Amin Firoozi, Zohreh Tavassoli, Amir Shojaei, Narges Hosseinmardi, Javad Mirnajafi-Zadeh, Kristi Anne Kohlmeier, Yaghoub Fathollahi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amir RezagholizadehDepartment of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, PO Box 14115-111, Tehran, Iran.
Amin FirooziDepartment of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Zohreh TavassoliDepartment of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, PO Box 14115-111, Tehran, Iran.
Amir ShojaeiDepartment of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, PO Box 14115-111, Tehran, Iran.
Narges HosseinmardiDepartment of Physiology, Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Javad Mirnajafi-ZadehDepartment of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, PO Box 14115-111, Tehran, Iran.
Kristi Anne KohlmeierDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Yaghoub FathollahiDepartment of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, PO Box 14115-111, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study was conducted with aim of investigating the consequences of sleep deprivation (SD) on cognitive functions. For this purpose, adult male rats were subjected to SD protocol for 5 h. The SD and the control rats were trained in the Morris water maze (MWM) to assess spatial behavioral deficits due to the SD protocol. To determine the role of astrocytes in spatial navigation deficits associated with SD, an inhibitor of astrocyte activation, fluorocitrate (FC), or a suppressor of astrocyte activation, vitamin D, was injected into the dorsal-CA1 hippocampus before subjecting rats to the SD protocol and the effects of these compounds on spatial navigation deficits associated with SD in the MWM were assessed. As expected, 5 h of SD impaired the Morris water navigation task in rats. FC injection into the dorsal-CA1 hippocampus before the SD protocol did not prevent the SD-induced cognitive deficits. Interestingly, injection of vitamin D into the dorsal-CA1 hippocampus prior to the SD protocol alleviated the SD-induced severe spatial navigation deficit in the MWM. Sequential injection of FC and vitamin D prior to the SD protocol did not reduce the SD-induced spatial memory impairment, suggesting a role for astrocytes. In sum, vitamin D can improve cognitive dysfunction associated with sleep deprivation, possibly dependent on astrocyte function. The results show that maintaining adequate levels of vitamin D offers a promising avenue to improve cognitive function in sleep-deprived conditions.

Indexed as

AstrocytesGlial activation suppressorGlial metabolic inhibitorHippocampusLearning and memorySleep deprivation

Identifiers

PMID39959779
PMCPMC11829095

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.