ArticleNeurosurgery practice2023
Changes in Distributed Motor Network Connectivity Correlates With Functional Outcome After Surgical Resection of Brain Tumors.
Article in Neurosurgery practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Supplementary motor area syndrome in intracranial gliomas is not associated with worse survival.Journal of neuro-oncology · 2026Article
- Different Brain Network Connectomic Relationships Subserve Hand Dexterity During Task Versus Resting States in People with Brain Tumors.Brain and behavior · 2025Article
- Altered functional connectivity associated with striatal dopamine depletion in Parkinson's disease.Cerebral cortex communications · 2023Article
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Authors and funding
13 authors.
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Abstract
backgroundIn patients with brain tumors around the motor cortices, deterioration of motor performance may be observed even if the integrity of the cortical output is maintained. Especially, resection of medial premotor area (PM) can cause postoperative deterioration called supplementary motor area syndrome.
objectiveTo clarify the neuronal mechanisms underlying postsurgical deterioration with a case-control study.
methodsTwelve patients with brain tumors underwent preoperative and postoperative sessions consisting of motor performance evaluation and 3T-magnetic resonance imaging data acquisition. Based on additional postsurgical motor deficits, 6 patients were classified into "deficit group," and 6 others were into "no deficit group." Using resting-state functional magnetic resonance imaging (fMRI), the integrity of functional connectivity was evaluated by placing a seed in the ipsilesional primary motor area (M1). With motor task fMRI, hand and foot representations were identified in the M1 and lateral and medial PMs. Probabilistic tractography assessed anatomic connectivity in the cortico-cortical and corticofugal networks.
resultsFunctional connectivity among M1 and lateral and medial PMs during resting-state fMRI was reduced postoperatively in the deficit group (
conclusionThe present findings suggest that supplementary motor area syndrome is caused by disorganization of functional connectivity among cortical motor networks rather than resection of anatomic connectivity of corticofugal pathway.
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