ArticleAesthetic surgery journal. Open forum2025
Histopathological Analysis of Abdominal Skin and Fat After In Vivo Hyperthermia-Induced Lipolysis With a 1064 nm Diode Laser, Radiofrequency, and Electromagnetic Field: A Pilot Study.
Article in Aesthetic surgery journal. Open forum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Fascia-Level Temperature Kinetics During Multi-Wavelength Diode Laser Irradiation: A Cadaveric Study.Journal of cosmetic dermatology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Hyperthermic laser lipolysis safely reduces unwanted fat through controlled thermal injury of adipocytes. Objectives: To assess the effects of 1064 nm laser, single vs multiple treatments, with and without radiofrequency (RF) and pulsed electromagnetic field (PEMF) energy on abdominal tissue. Methods: Nine volunteers scheduled for elective abdominoplasty were divided into 1 of 3 arms: (1) laser alone, (2) laser with and without RF and PEMF, and (3) multiple vs single laser treatments. Untreated (control) and treated tissues were collected at various time points following treatment. Paraffin sections from surgically excised pannus were evaluated with Masson's trichrome, apoptosis (TUNEL), Collagen 1, Collagen 3, Elastin, and CD68 macrophage markers. Results: All study arms showed subdermal adipose tissue lysis without compromising epidermal or dermal integrity. Apoptotic adipocytes and macrophage infiltration were present in areas of structural damage. Adjuvant RF and PEMF showed increased macrophage infiltration after 14 days. Multiple 1064 nm treatments induced apoptosis in subcutaneous adipocytes. There were no significant changes in dermal Collagen 1, Collagen 3, and elastin abundance. Conclusions: The 1064 nm diode laser can destroy adipocytes without harming overlying epidermis. RF enhances lipolytic effects of the laser with increased inflammation and tissue remodeling, whereas PEMF therapy uses electromagnetic fields to stimulate cell function and tissue repair. These findings suggest the 1064 nm diode laser can achieve intended effects. Level of Evidence 3 Therapeutic:
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Registered trials
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