ArticleAmerican journal of translational research2025
The effect of rivaroxaban as an anticoagulant therapy for acute pulmonary embolism and the predictive role of vascular endothelial markers in assessing anticoagulant efficacy before treatment.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Abstract
backgroundAcute pulmonary embolism (PE) is a life-threatening condition requiring effective anticoagulation therapy. Rivaroxaban, a direct oral anticoagulant, offers advantages over warfarin, yet individual patient responses vary. This study examined the efficacy of rivaroxaban compared to warfarin and evaluated vascular endothelial markers as predictors of anticoagulant efficacy.
methodsWe conducted a retrospective cross-over cohort study involving 295 patients with acute PE, comparing rivaroxaban (n = 158) and warfarin (n = 137) treatments. Clinical efficacy was assessed based on symptomatic improvement and imaging results. Vascular endothelial markers, including soluble thrombomodulin (sTM), circulating endothelial cells (CEC), and endothelin-1 (ET-1), were examined for their predictive capability in treatment outcomes, then the data of 97 additional patients were used for external validation.
resultsPatients who received rivaroxaban showed higher overall treatment response (93.04%) compared to those who took warfarin (74.45%;
conclusionRivaroxaban was more effective than warfarin in treating acute PE, with specific vascular endothelial markers serving as promising predictors of therapeutic response.
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