ArticleAmerican journal of translational research2025
Mechanistic study of Erianin in alopecia areata.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Pharmacological activity, molecular mechanisms and therapeutic potential of erianin (Review).International journal of molecular medicine · 2026Review
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Authors and funding
9 authors.
Funding
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Abstract
objectiveTo investigate the role and mechanisms of Erianin in treating alopecia areata.
methodsA C3H/HeJ AA mouse model was established using skin transfer or adoptive T-cell transfer. All mice received either systemic or topical treatments. Photographic documentation was used to monitor hair growth, which was quantified using G*Power software. Infiltrating inflammatory markers in the skin were assessed using immunofluorescence staining, and the infiltrating immune cell populations in the skin and subcutaneous draining lymph nodes (SDLNs) were analyzed using flow cytometry.
resultsErianin effectively inhibited the function of effector T cells, significantly suppressing Alopecia Areata (AA) in C3H/HeJ transplanted mice. It also reversed systemic manifestations of AA and effectively promoted hair growth in AA mice.
conclusionErianin demonstrates a potent therapeutic effect on AA, primarily through modulation of T cell immune function.
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