Evidence map›Paper›PMID 39959168›Full record

ArticleMolecular vision2024

Peroxisome proliferator-activated receptor-α affects corneal epithelial wound healing.

Yang Wu, Jinghua Bu, Rongrong Zhang, Le Sun, Yuanzhi Yuan, Wei Li

Abstract read
In one paragraph

Article in Molecular vision, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Fenofibrate in ophthalmology: therapeutic efficacy and mechanisms.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yang WuZhongshan Hospital (Xiamen), Fudan University, Xiamen, Fujian, China.
Jinghua BuDepartment of Ophthalmology, Xiang'an Hospital of Xiamen University; Eye Institute of Xiamen University; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science; Fujian Engineering and Research Center of Eye Regenerative Medicine; School of Medicine, Xiamen University. Xiamen, Fujian, China.
Rongrong ZhangDepartment of Ophthalmology, Xiang'an Hospital of Xiamen University; Eye Institute of Xiamen University; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science; Fujian Engineering and Research Center of Eye Regenerative Medicine; School of Medicine, Xiamen University. Xiamen, Fujian, China.
Le SunDepartment of Ophthalmology, Xiang'an Hospital of Xiamen University; Eye Institute of Xiamen University; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science; Fujian Engineering and Research Center of Eye Regenerative Medicine; School of Medicine, Xiamen University. Xiamen, Fujian, China.
Yuanzhi YuanZhongshan Hospital (Xiamen), Fudan University, Xiamen, Fujian, China.
Wei LiDepartment of Ophthalmology, Xiang'an Hospital of Xiamen University; Eye Institute of Xiamen University; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science; Fujian Engineering and Research Center of Eye Regenerative Medicine; School of Medicine, Xiamen University. Xiamen, Fujian, China.

Funding

DEVELOPMENT OF SYNAPTIC PATHWAYS IN RETINAR01EY012345 · NEI · YALE UNIVERSITY · PI TIAN, NING · 1999 to 2015
$5.1M
NEI NIH HHS R01 EY012345
6 · The paper itself

Abstract

Purpose: This study aimed to determine the role of peroxisome proliferator-activated receptor α (PPARα) on corneal epithelial wound healing. Methods: Ten-week-old PPARα knockout ( Results: PPARα expression was found to significantly increase during corneal epithelial repair. Conclusions: PPARα is a regulator of corneal epithelial wound healing, and its absence leads to delayed repair processes in the corneal epithelium.

Indexed as

Epithelium, CornealPPAR alphaWound HealingAnimalsCell ProliferationCells, CulturedCorneal InjuriesEpithelial CellsFenofibrateHumansMiceMice, Inbred C57BLMice, KnockoutFenofibratePPAR alpha

Identifiers

PMID39959168
PMCPMC11829788

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.