Trial reportDrug design, development and therapy2025
Determination of the MEC90 of Oxycodone for Preventing Perioperative Shivering in Pregnant Patients Undergoing Caesarean Delivery with Neuraxial Anaesthesia: A Biased-Coin up-and-Down Sequential Allocation Trial.
Trial report in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Perioperative shivering is a common adverse reaction to neuraxial anaesthesia. Intravenous oxycodone can be used to prevent shivering. However, few trials have been conducted on the use of oxycodone to prevent shivering, and the optimal dose is unknown. This study aimed to determine the optimal dose (90% minimum effective concentration [MEC90]) of intraoperative oxycodone to prevent shivering during caesarean section. Methods: This study was designed by the biased-coin up-and-down method. We recruited pregnant women who underwent caesarean section under combined spinal-epidural anaesthesia. Oxycodone was administered intravenously after the delivery of the foetus. The initial dose was 80 µg/kg, and subsequent dose adjustments were determined by up-and-down sequential allocation using a biased-coin design based on the response of the previous patient. The primary outcome was the MEC90 for oxycodone injection based on the success or failure of the shivering-preventing dose. Results: Fifty patients were enrolled in the study. The oxycodone dose ranged from 80 to 95 µg/kg. The estimated MEC90 (95% confidence interval [CI]) for preventing shivering was 88.1 µg/kg (81.5-92.5 µg/kg). The patient's postoperative temperature was 36.5 ± 0.2 °C. The incidence of intraoperative traction pain was 12%. The 5-min and 30-min Ramsay sedation scores were 3 (3-4) and 3 (3-3), respectively. The 2-h and 6-h postoperative VAS scores were 3 (2-3) and 4 (3-5), respectively. The patient's anaesthesia satisfaction score was 5 (4-5). The incidence of respiratory depression was 2%, and the incidence of nausea and vomiting was 16%. Conclusion: The MEC90 of intraoperative intravenous oxycodone for the prevention of shivering in women undergoing caesarean section with neuraxial anaesthesia was 88.1 µg/kg (95% CI: 81.5-92.5 µg/kg).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.