Evidence map›Paper›PMID 39959037›Full record

ArticleACS omega2025

Improving the Activity and Selectivity of a Scorpion-Derived Peptide, A3a, against

Dalton S Möller, Mandelie van der Walt, Carel Oosthuizen, Miruna Serian, June C Serem, Christian D Lorenz, A James Mason, Megan J Bester, Anabella R M Gaspar

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In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dalton S MöllerDepartment of Biochemistry, Genetics and Microbiology, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria 0002, South Africa.
Mandelie van der WaltDepartment of Biochemistry, Genetics and Microbiology, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria 0002, South Africa.
Carel OosthuizenDrug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch 7701, South Africa.ORCID https://orcid.org/0000-0003-0940-8099
Miruna SerianDepartment of Physics, Faculty of Natural, Mathematical and Engineering Sciences, King's College London, London WC2R 2LS, U.K.
June C SeremDepartment of Anatomy, Faculty of Health Sciences, University of Pretoria, Pretoria 0002, South Africa.
Christian D LorenzDepartment of Engineering, Faculty of Natural, Mathematical and Engineering Sciences, King's College London, London WC2R 2LS, U.K.ORCID https://orcid.org/0000-0003-1028-4804
A James MasonInstitute of Pharmaceutical Science, School of Cancer & Pharmaceutical Science, Faculty of Life Sciences & Medicine, King's College London, London SE1 9NH, U.K.ORCID https://orcid.org/0000-0003-0411-602X
Megan J BesterDepartment of Anatomy, Faculty of Health Sciences, University of Pretoria, Pretoria 0002, South Africa.
Anabella R M GasparDepartment of Biochemistry, Genetics and Microbiology, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria 0002, South Africa.ORCID https://orcid.org/0000-0003-2035-3084

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rise in antimicrobial resistance has led to an increased desire to understand how antimicrobial peptides (AMPs) can be better engineered to kill antibiotic-resistant bacteria. Previously, we showed that C-terminal amidation of a peptide, identified in scorpion

Identifiers

PMID39959037
PMCPMC11822712

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.