Evidence map›Paper›PMID 39958982›Full record

ArticleInfection and drug resistance2025

Pyrvinium Pamoate Synergizes with Azoles in vitro and in vivo to Exert Antifungal Efficacy Against

Jinqing Zhang, Gaolian Li, Jing Hu, Jingwen Tan, Heng Zhang, Yizheng Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and drug resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jinqing Zhang *Department of Dermatology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People's Republic of China.
Gaolian Li *Department of Gynaecology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei Province, People's Republic of China.
Jing Hu *Department of Clinical Medicine, Xiangyang Polytechnic, Xiangyang, Hubei Province, People's Republic of China.
Jingwen TanDepartment of Medical Mycology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
Heng ZhangDepartment of Clinical Laboratory, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei Province, People's Republic of China.
Yizheng ZhouDepartment of Clinical Laboratory, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei Province, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Treating infections caused by azole-resistant Materials and Methods: A total of 21 clinical Results: When used to treat these different fungal isolates in vitro, the single-agent efficacy of PP was relatively poor, with minimum inhibitory concentration values ranging from 2 μg/mL - >32 μg/mL. However, PP and azoles exhibited synergistic activity against the majority of analyzed Conclusion: Combining PP with azoles represents a promising approach to effectively disrupting the growth of azole-resistant

Indexed as

Candida aurisGalleria mellonellapyrvinium pamoatesynergy azoles

Identifiers

PMID39958982
PMCPMC11827495

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.