Evidence map›Paper›PMID 39958979›Full record

ArticleOpen medicine (Warsaw, Poland)2025

The era of increasing cancer survivorship: Trends in fertility preservation, medico-legal implications, and ethical challenges.

Lina De Paola, Gabriele Napoletano, Giuseppe Gullo, Francesco Circosta, Gianluca Montanari Vergallo, Susanna Marinelli

Abstract read
In one paragraph

Article in Open medicine (Warsaw, Poland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
  2. Review
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  4. Counseling and use of surrogacy among cancer survivors (CUSACS).Journal of cancer survivorship : research and practice · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lina De PaolaDepartment of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, Rome, Italy.
Gabriele NapoletanoDepartment of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, Rome, Italy.
Giuseppe GulloDepartment of Obstetrics and Gynecology, Villa Sofia Cervello Hospital, University of Palermo, Palermo, 90146, Italy.
Francesco CircostaDepartment of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, "Sapienza" University of Rome, Rome, Italy.
Gianluca Montanari VergalloDepartment of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, Rome, Italy.
Susanna MarinelliSchool of Law, Polytechnic University of Marche, 60121, Ancona, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Global cancer cases are increasing, but fortunately, cancer is becoming more treatable. By 2050, the number of cancer cases is projected to reach 35 million. These numbers are certainly correlated with the aging population, early diagnoses due to screenings, and the broad current treatment options. However, life-saving therapies are often gonadotoxic, significantly impacting the lives of cancer patients. Fertility preservation following life-saving oncological treatments is one of the challenges faced by patients with cancer. Material and method: We analyzed 73 articles to investigate the current state of fertility preservation in oncology, also evaluating the medico-legal implications. Results: The data indicate a growing trend of cancer recoveries and survivorship with opportunities to access fertility preservation through various methods, which are not entirely known or consistently offered to patients in the appropriate manner. Conclusions: The ethical and medico-legal aspects are numerous and seem to be still evolving.

Indexed as

cancerethic/legal implicationfertility preservationoncology

Identifiers

PMID39958979
PMCPMC11826245

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.