Evidence map›Paper›PMID 39958865›Full record

ArticleBiomedical optics express2025

Development of next generation low-cost OCT towards improved point-of-care retinal imaging.

Hillel B Price, Ge Song, Wan Wang, Erin O'Kane, Kechao Lu, Evan Jelly, David A Miller, Adam Wax

Abstract read
In one paragraph

Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hillel B PriceDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.ORCID https://orcid.org/0000-0002-5299-9421
Ge SongDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Wan WangDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Erin O'KaneDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.ORCID https://orcid.org/0009-0007-6186-4688
Kechao LuDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Evan JellyDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.ORCID https://orcid.org/0000-0003-4678-9716
David A MillerDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.ORCID https://orcid.org/0000-0002-1630-1233
Adam WaxDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.ORCID https://orcid.org/0000-0002-1827-5112

Funding

Retinal Light Scattering Measurements as a Clinical Biomarker of Alzheimer's DiseaseR01AG072732 · NIA · DUKE UNIVERSITY · PI Adam Wax · 2022 to 2026
$2.4M
NIA NIH HHS R01 AG072732
6 · The paper itself

Abstract

Low-cost optical coherence tomography (OCT) has shown promise in increasing access to noninvasive retinal imaging at the point of care, especially in low-resource environments. A next-generation low-cost OCT system is presented which improves performance over previous versions by employing balanced detection, improved spectrometer falloff, and an increased A-line rate of 40 kHz. An algorithm is presented for image display that uses a histogram matching procedure to improve contrast-to-noise ratio (CNR). Imaging performance is benchmarked with CNR analysis of retinal OCT images, demonstrating a CNR of 2.01 ± 0.39 (p < 0.0001) for macula images collected during a clinical trial, a significant improvement over previous low-cost OCT systems.

Identifiers

PMID39958865
PMCPMC11828462

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.