Evidence map›Paper›PMID 39958659›Full record

ArticleEndoscopy international open2025

US multicenter outcomes of endoscopic ultrasound-guided gallbladder drainage with lumen-apposing metal stents for acute cholecystitis.

Yakira David, Gaurav Kakked, Bradley Confer, Ruchit Shah, Harshit Khara, David L Diehl, Matthew Richard Krafft, Sardar M Shah-Khan, John Y Nasr, Petros Benias and 45 more

Registry-linked trialAbstract read
In one paragraph

Article in Endoscopy international open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07655778 (Multicenter Comparative Clinical Trial), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07655778 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Multicenter Comparative Clinical Trial: EUS-Guided Gallbladder Drainage Versus Conservative Management in Patients Unfit for Surgery After a Biliary Event Without Cholecystitis. DRECON Study: (DRainage, Endoscopic Ultrasound, CONservative)

TypeinterventionalSponsorHospital Mutua de TerrassaRan2026 to 2029Enrolled110ConditionsCholecystectomy, Gallbladder, Endoscopic Ultrasound (EUS), CholelithiasisArmsEUS-guided gallbladder drainage (EUS-GBD), Conservative management (CM)
3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Toward Tailored EUS-Guided Gallbladder Drainage in the Era of Lumen-Apposing Metal Stent.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Natural orifice surgery for rescue of stent misplacement in endoscopic gallbladder drainage.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2025
    Article
  8. Review
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

55 authors.

Yakira DavidGastroenterology, Mayo Clinic College of Medicine and Science, Rochester, United States.
Gaurav KakkedRush University Medical Center, Chicago, United States.
Bradley ConferGastroenterology and Nutrition, Geisinger Medical Center, Danville, United States.
Ruchit ShahGeisinger Medical Center, Danville, United States.
Harshit KharaGeisinger Medical Center, Danville, United States.
David L DiehlGastroenterology and Nutrition, Geisinger Medical Center, Danville, United States.ORCID 0000-0003-4128-3839
Matthew Richard KrafftDigestive Diseases, Ruby Memorial Hospital, Morgantown, United States.ORCID 0000-0002-2291-8977
Sardar M Shah-KhanGastroenterology, Rutgers Robert Wood Johnson Medical School New Brunswick, New Brunswick, United States.
John Y NasrDigestive Diseases, West Virginia University School of Medicine, Morgantown, United States.
Petros BeniasRutgers University, New Brunswick, United States.
Arvind TrindadeNorth Shore Long Island Jewish Medical Center, New Hyde Park, United States.
Thiruvengadam MunirajYale University, New Haven, United States.
Harry AslanianDepartment of Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, United States.
Prabhleen ChahalCleveland Clinic, Cleveland, United States.
John RodriguezCleveland Clinic, Cleveland, United States.
Douglas G AdlerGastroenterology, University of Utah School of Medicine, Salt Lake City, United States.
Jason DubroffUniversity of Utah Health, Salt Lake City, United States.
Rabi De LatourNYU Langone Health, New York, United States.
Demetrios TzimasNorthwell Health, New Hyde Park, United States.
Lauren KhannaNYU Langone Health, New York, United States.
Gregory HaberNYU Langone Health, New York, United States.
Adam J GoodmanGastroenterology, NYU Langone Medical Center, New York, United States.
Nicholas HoerterIcahn School of Medicine at Mount Sinai, New York, United States.
Nishi PandeyBayonne Medical Center, Bayonne, United States.
Mena BakhitBrown University Warren Alpert Medical School, Providence, United States.
Thomas E KowalskiGastroenterology, Thomas Jefferson University - Center City Campus, Philadelphia, United States.
David LorenFox Chase Cancer Center, Philadelphia, United States.
Austin ChiangThomas Jefferson University Hospital JeffSTAT Education Center, Philadelphia, United States.
Alexander SchlachtermanDivision of Gastroenterology, Hepatology & Nutrition, University of Florida, Gainesville, United States.
Jose NietoGastroenterology, Borland-Groover Clinic, Jacksonville, United States.
Ameya DeshmukhSaint Louis University, St Louis, United States.
Yervant IchkhanianIndiana University, Bloomington, United States.
Mouen A KhashabGastroenterology, Johns Hopkins Hospital, Baltimore, United States.
Maan El HalabiTufts Medical Center, Boston, United States.
Richard S KwonInternal Medicine, Univ Michigan, Ann Arbor, United States.
Anoop PrabhuRoswell Park Comprehensive Cancer Center, Buffalo, United States.
Ariosto Hernandez-LaraMayo Foundation for Medical Education and Research, Rochester, United States.
Andrew StormMayo Foundation for Medical Education and Research, Rochester, United States.
Tyler M BerzinGastroenterology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, United States.
John PonerosDigestive and Liver Diseases, Columbia University Medical Center, New York, United States.
Amrita SethiColumbia Presbyterian Medical Center, New York, United States.
Tamas A GondaDigestive and Liver Diseases, Columbia University Medical Center, NYC, United States.
Vladimir KushnirWashington University in St Louis, St Louis, United States.
Natalie CosgroveGastroenterology & Hepatology, Thomas Jefferson University, Philadelphia, United States.
Daniel MulladyWashington University in St Louis, St Louis, United States.
Abdullah Al-ShahraniCU Anschutz Medical Campus, Aurora, United States.
Lionel D'SouzaStony Brook University Hospital, Stony Brook, United States.
Jonathan BuscagliaDivision of Gastroenterology, State University of New York, Stony Brook, United States.
Juan Carlos BucoboNorth Shore University Hospital, Manhasset, United States.
Vineet RolstonMemorial Sloan Kettering Cancer Center, New York, United States.
Prashant KediaGastroenterology, Methodist Dallas Medical Center, Dallas, United States.
Franklin KasminHCA Florida Aventura Hospital and Medical Center, Aventura, United States.
Satish NagulaMedicine, Icahn School of Medicine at Mount Sinai, New York, United States.
Nikhil A KumtaDr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, United States.
Christopher DiMaioCatholic Health St Francis Hospital & Heart Center, Roslyn, United States.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

Background and study aims: EUS-guided gallbladder drainage (EUS-GBD) using lumen apposing metal stents (LAMS) has excellent technical and short-term clinical success for acute cholecystitis (AC). The goals of this study were to determine the long-term clinical outcomes and adverse events (AEs) of EUS-GBD with LAMS. Patients and methods: A multicenter, retrospective study was conducted at 18 US tertiary care institutions. Inclusion criteria: any AC patient with attempted EUS-GBD with LAMS and minimum 30-day post-procedure follow-up. Long-term clinical success was defined as absence of recurrent acute cholecystitis (RAC) > 30 days and long-term AE was defined as occurring > 30 days from the index procedure. Results: A total of 109 patients were included. Technical success was achieved in 108 of 109 (99.1%) and initial clinical success in 106 of 109 (97.2%). Long-term clinical success was achieved in 98 of 109 (89.9%) over a median follow-up of 140 days (range 30-1188). On multivariable analysis (MVA), acalculous cholecystitis (odds ratio [OR] 15.93, 95% confidence interval [CI] 1.22-208.52, Conclusions: EUS-GBD with LAMS has a high rate of long-term clinical success and modest AE rates in patients with AC and is a reasonable destination therapy for high-risk surgical candidates.

Indexed as

Biliary tractEndoscopic ultrasonographyIntervention EUSPerformance and complicationsQuality and logistical aspects

Identifiers

PMID39958659
PMCPMC11827723

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.