ArticleBiocybernetics and biomedical engineering
Impact of aging on anterior segment morphology and aqueous humor dynamics in human Eyes: Advanced imaging and computational techniques.
Article in Biocybernetics and biomedical engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Ultrasound biomicroscopy-based quantitative assessment of anterior segment biometric changes in contralateral eyes of unilateral neovascular glaucoma: a retrospective case-control study.Frontiers in medicine · 2026Article
- A quantum-inspired neural fuzzy sliding mode control framework for fractional-order modeling of intraocular pressure regulation and optic nerve damage in glaucoma.Scientific reports · 2025Article
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Authors and funding
13 authors.
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Abstract
Objective: Aging results in significant structural and functional changes in the anterior segment of the eye, influencing intraocular pressure (IOP) and overall ocular health. Although aging is a well-established risk factor for primary open-angle glaucoma, a leading cause of irreversible blindness, the specific mechanisms through which aging drives morphological changes in anterior segment tissues and affects aqueous humor dynamics remain incompletely understood. Methods: In this study, we employed cutting-edge light sheet fluorescence microscopy (LSFM) to capture high-resolution, volumetric images of cleared human donor eyes' anterior segment tissues. This advanced imaging enabled a comprehensive morphological analysis of key parameters, including central and peripheral corneal thickness (CCT and PCT), iris thickness, anterior chamber area (ACA), and ciliary body area (CBA). By integrating these morphological parameters with computational fluid dynamics (CFD) models, we analyzed aqueous humor dynamics across Results: The CCT and PCT demonstrated thinning with age, accompanied by a reduction in ACA. In contrast, the CBA remained relatively stable across all age groups. Computational fluid dynamics analysis showed a decline in aqueous humor velocity and wall shear stress, with younger eyes exhibiting higher velocities and shear stress, compared to older eyes. Conclusion: These findings emphasize the value of integrating LSFM and CFD approaches to provide a detailed understanding of how aging impacts the anterior segment and its fluid dynamics. This study contributes to the understanding of age-related ocular changes, highlighting the importance of considering these changes in the diagnosis and management of age-related eye diseases.
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