ArticleFrontiers in neurology2025
Identifying the predictors of ultra early neurological improvement and its role in functional outcome after endovascular thrombectomy in acute ischemic stroke.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Decompressive craniectomy after endovascular thrombectomy in acute ischemic stroke: a systematic review.Acta neurochirurgica · 2025Pooled it
- Early Postthrombectomy Neurological Improvement: the NIHSS Drop as an Immediate Predictor of Good Functional Outcomes.Clinical neuroradiology · 2026Article
- Development of a simple clinical score to predict early neurological improvement after mechanical thrombectomy: a single-centre cohort study.BMC neurology · 2026Article
- [A prediction model for early neurological improvement after intravenous thrombolysis in patients with acute ischemic stroke].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Article
- Predictors of functional outcome at 3 months in ischemic stroke patients with discharge disability following endovascular therapy: a multi-center observational cohort study of 836 patients.Acta neurochirurgica · 2026Observational
- Observational
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Authors and funding
13 authors.
Funding
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Abstract
Background and purpose: Using post-treatment methods to predict functional outcomes of acute ischemic stroke (AIS) patients undergoing endovascular thrombectomy (EVT) is crucial in stroke medicine. The National Institute of Health Stroke Scale (NIHSS) score at 24 h has been widely used; however, there is a paucity of data on using earlier NIHSS scores and their association with outcome. In this study, we aimed to investigate the usage of NIHSS at 1-h time window -ultra-early neurological improvement (UENI)- as a surrogate marker associated with the functional outcomes of AIS patients treated with EVT. Methods: We included 485 adults (≥18 years old) who underwent emergency EVT at four academic comprehensive stroke centers between 2020 and 2021. Patients with pre-EVT Alberta Stroke Program Early CT Score (ASPECTS) < 6, missing follow-up data, and missing data of the first hour NIHSS were excluded ( Results: A total of 465 patients were included in our final analysis. We identified 122 (26.2%) patients with UENI. While 82.79% of the patients with UENI achieved favorable functional outcomes at 3-months, only 32.36% of patients without UENI had favorable functional outcome ( Conclusion: UENI was observed in about a quarter of patients with AIS undergoing EVT. Younger age, shorter LKNPT, higher pre-treatment ASPECTS, final mTICI≥2b, and fewer number of EVT attempts, were independently associated with UENI. The presence of UENI was independently associated with better functional outcome at 3 months.
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