Evidence map›Paper›PMID 39958610›Full record

ArticleFrontiers in nutrition2024

Transitioning of protein substitutes in patients with phenylketonuria: a pilot study.

Ozlem Yilmaz Nas, Catherine Ashmore, Sharon Evans, Alex Pinto, Anne Daly, Nurcan Yabanci Ayhan, Anita MacDonald

Abstract read
In one paragraph

Article in Frontiers in nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Observational
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ozlem Yilmaz NasDepartment of Clinical Inherited Metabolic Disorders, Birmingham Children's Hospital, Birmingham, United Kingdom.
Catherine AshmoreDepartment of Clinical Inherited Metabolic Disorders, Birmingham Children's Hospital, Birmingham, United Kingdom.
Sharon EvansDepartment of Clinical Inherited Metabolic Disorders, Birmingham Children's Hospital, Birmingham, United Kingdom.
Alex PintoDepartment of Clinical Inherited Metabolic Disorders, Birmingham Children's Hospital, Birmingham, United Kingdom.
Anne DalyDepartment of Clinical Inherited Metabolic Disorders, Birmingham Children's Hospital, Birmingham, United Kingdom.
Nurcan Yabanci AyhanDepartment of Nutrition and Dietetics, Ankara University, Ankara, Türkiye.
Anita MacDonaldDepartment of Clinical Inherited Metabolic Disorders, Birmingham Children's Hospital, Birmingham, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: In phenylketonuria (PKU), there is limited information about transitioning between protein substitutes and the influencing factors, particularly in young children. This pilot study assessed the stepwise transition from second to third-stage protein substitutes in children with PKU, aged 3-5 years. Methods: Demographics, child behavior, maternal anxiety, and food neophobia scores were collected at baseline, mid-transition, and final assessment. Blood phenylalanine (Phe) was collected from 6 months pre-baseline to post-final assessment. Results: Twelve children ( Conclusion: A stepwise transition to third-stage protein substitutes in PKU is effective, but is dependent on child metabolic control, parental education, and nursery/school support.

Indexed as

guidanceliquidpowderprotein substituteready-to-drinkstepwisetransition

Identifiers

PMID39958610
PMCPMC11825342

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.