Evidence map›Paper›PMID 39958586›Full record

ArticleMissouri medicine

Advanced Technology Clinic Provides Personalized Approach to Pediatric Epilepsy Surgery: Early Data and Future Directions.

Esra Pehlivan, John Zempel, Janette Coble, Sara Graves, Sean McEvoy, Matt Smyth, Kwee Liu Lin Thio, Christina Gurnett, Jarod Roland, Réjean M Guerriero and 1 more

Abstract read
PubMed Full text at PMC
In one paragraph

Article in Missouri medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Esra PehlivanDivision of Pediatric and Developmental Neurology, Department of Neurology. Washington University School of Medicine, St. Louis, Missouri.
John ZempelDivision of Pediatric and Developmental Neurology, Department of Neurology. Washington University School of Medicine, St. Louis, Missouri.
Janette CobleDivision of Pediatric and Developmental Neurology, Department of Neurology. Washington University School of Medicine, St. Louis, Missouri.
Sara GravesDivision of Pediatric and Developmental Neurology, Department of Neurology. Washington University School of Medicine, St. Louis, Missouri.
Sean McEvoyDivision of Pediatric Neurosurgery, Department of Neurology, Washington University School of Medicine, St. Louis, Missouri.
Matt SmythDivision of Pediatric Neurosurgery, Department of Neurology, Washington University School of Medicine, St. Louis, Missouri. Division of Pediatric Neurosurgery, Johns Hopkins All Children's Hospital, St. Petersburg, Florida.
Kwee Liu Lin ThioDivision of Pediatric and Developmental Neurology, Department of Neurology. Washington University School of Medicine, St. Louis, Missouri.
Christina GurnettDivision of Pediatric and Developmental Neurology, Department of Neurology. Washington University School of Medicine, St. Louis, Missouri.
Jarod RolandDivision of Pediatric Neurosurgery, Department of Neurology, Washington University School of Medicine, St. Louis, Missouri.
Réjean M GuerrieroDivision of Pediatric and Developmental Neurology, Department of Neurology. Washington University School of Medicine, St. Louis, Missouri.
Stuart R TomkoDivision of Pediatric and Developmental Neurology, Department of Neurology. Washington University School of Medicine, St. Louis, Missouri.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Postoperative improvement in seizures may impact quality of life. We examined the relationship between reduced seizure burden and quality of life in a surgical epilepsy clinic. Methods: We reviewed data from all children who received epilepsy surgery at our center. Surgeries were classified as palliative or definitive based on the seizure outcome goals. We collected demographics, surgical data, Engel classification, and quality of life outcomes. Results: Between 2016 and 2024, 282 patients underwent 338 surgeries. In the definitive surgery group, 66 patients (58%) attained an Engel 1 outcome at six months and 46 patients (58%) at 24 months. In the palliative surgery group, six patients (7%) attained an Engel 1 outcome at six months. At 12 months, 75% of patients who attained Engel 1 reported lower depression scores. Conclusion: Improvement in seizure burden and quality of life outcomes following epilepsy surgery may be related. Further outcomes research is required.

Indexed as

EpilepsyPrecision MedicineAdolescentChildChild, PreschoolFemaleHumansInfantMaleNeurosurgical ProceduresQuality of LifeRetrospective StudiesSeizuresTreatment Outcome

Identifiers

PMID39958586
PMCPMC11827649

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.