Evidence map›Paper›PMID 39958533›Full record

ArticleWorld journal of gastrointestinal oncology2025

Relationship between gastric mucosal atrophy by endoscopy and non-ampullary duodenal epithelial tumors.

Kazuya Ohno, Eiji Nakatani, Takafumi Kurokami, Asami Kawai, Ryosuke Itai, Masanori Matsuda, Yuichi Masui, Tatsunori Satoh, Shinya Ikeda, Taiyo Hirata and 3 more

Abstract read
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In one paragraph

Article in World journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Kazuya OhnoDepartment of Gastroenterology, Shizuoka General Hospital, Shizuoka 420-8527, Japan.
Eiji NakataniResearch Support Center, Graduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka 420-0881, Japan.
Takafumi KurokamiDepartment of Gastroenterology, Shizuoka General Hospital, Shizuoka 420-8527, Japan.
Asami KawaiDepartment of Gastroenterology, Shizuoka General Hospital, Shizuoka 420-8527, Japan.
Ryosuke ItaiDepartment of Gastroenterology, Shizuoka General Hospital, Shizuoka 420-8527, Japan.
Masanori MatsudaDepartment of Gastroenterology, Shizuoka General Hospital, Shizuoka 420-8527, Japan.
Yuichi MasuiDepartment of Gastroenterology, Shizuoka General Hospital, Shizuoka 420-8527, Japan.
Tatsunori SatohDepartment of Gastroenterology, Shizuoka General Hospital, Shizuoka 420-8527, Japan.
Shinya IkedaDepartment of Gastroenterology, Shizuoka General Hospital, Shizuoka 420-8527, Japan.
Taiyo HirataDepartment of Gastroenterology, Shizuoka General Hospital, Shizuoka 420-8527, Japan.
Shodai TakedaDepartment of Gastroenterology, Shizuoka General Hospital, Shizuoka 420-8527, Japan.
Makoto SuzukiDepartment of Pathology, Shizuoka General Hospital, Shizuoka 420-8527, Japan.
Ken HarumaDepartment of General Internal Medicine 2, Kawasaki Medical School, Okayama 700-8505, Japan. kharuma@med.kawasaki-m.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe pathogenesis of non-ampullary duodenal epithelial tumors (NADETs) is not fully understood. NADETs that express gastric-type mucin phenotypes (G-NADETs) are noteworthy because of their high malignancy. Gastric foveolar metaplasia, from which G-NADETs originate, protects the duodenal mucosa from gastric acidity. As gastric acid secretion is affected by endoscopic gastric mucosal atrophy (EGMA), we hypothesized that EGMA would be associated with G-NADETs.

aimTo evaluate the association between EGMA and the occurrence of G-NADETs.

methodsThis cross-sectional retrospective study investigated the relationship between EGMA and NADETs in 134 patients. The duodenum was divided into parts 1 (bulb), 2 (superior duodenal angle to the papilla), and 3 (anal side of the papilla to the horizontal part). The effects of gastric acidity and presence of Brunner's glands were considered. EGMA was divided into types C (no or mild atrophy) and O (severe atrophy). Mucin phenotype expressions in NADETs were divided into gastric, intestinal, gastrointestinal, and unclassifiable.

resultsWhen NADETs were classified according to EGMA, 105 were classified as type C and 29 as type O. G-NADETs were present in 11.9% (16 cases) of all cases, and all 16 cases were of type C. Among G-NADETs, 93.8% (15 cases) were present in part 1 or 2. There was an association between G-NADETs and type C in part 1, and 50.0% (eight of 16 cases) of G-NADETs were associated with a current or previous

conclusionG-NADETs were significantly associated with type C. Gastric acidity and Brunner's gland growth may be associated with G-NADETs.

Indexed as

Gastric acidityGastric foveolar metaplasiaGastric mucosal atrophyHelicobacter pyloriMucin phenotypeNon-ampullary duodenal epithelial tumor

Identifiers

PMID39958533
PMCPMC11756005

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