Evidence map›Paper›PMID 39958377›Full record

ArticleNeurosurgery practice2023

Diffusely Infiltrating Gliomas With Poor Prognosis,

Yoshihiro Tsukamoto, Manabu Natsumeda, Haruhiko Takahashi, Jotaro On, Hiroki Seto, Taiki Saito, Kohei Shibuya, Ryosuke Ogura, Junko Ito, Masayasu Okada and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurosurgery practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yoshihiro TsukamotoDepartment of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan.ORCID https://orcid.org/0000-0002-2311-5367
Manabu NatsumedaDepartment of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan.
Haruhiko TakahashiDepartment of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan.
Jotaro OnDepartment of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan.
Hiroki SetoDepartment of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan.
Taiki SaitoDepartment of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan.
Kohei ShibuyaDepartment of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan.
Ryosuke OguraDepartment of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan.
Junko ItoDepartment of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.
Masayasu OkadaDepartment of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan.
Makoto OishiDepartment of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan.
Hiroshi ShimizuDepartment of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.
Kouichirou OkamotoDepartment of Translational Research, Brain Research Institute, Niigata University, Niigata, Japan.
Akiyoshi KakitaDepartment of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.
Yukihiko FujiiDepartment of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPleomorphic xanthoastrocytoma (PXA) (World Health Organization grade II) is classified as a relatively benign and circumscribed glioma; however, anaplastic PXA (APXA, World Health Organization grade III) has a poorer prognosis, and differentiating from glioblastoma can be difficult both histologically and molecularly.

objectiveTo describe the clinical, pathological, and molecular characteristics of diffusely infiltrating gliomas with histological APXA-like features.

methodsFour diffusely infiltrating gliomas in adult patients histologically diagnosed as APXAs at a single institute were retrospectively reviewed. We analyzed their clinical, radiological, pathological, genetic, epigenetic, and prognostic characteristics.

resultsAll tumors histologically showed classical characteristic PXA-like appearance with

conclusionIn diffusely infiltrating gliomas showing histological characteristics of APXA, methylation classification should be performed as these tumors may be difficult to differentiate between glioblastoma, IDH-wildtype by histological or genetic analysis. The aggressive nature of these tumors should be expected, especially in cases that are

Indexed as

Anaplastic pleomorphic xanthoastrocytomaCDKN2A/2BGlioblastomaMRITERT promotor

Identifiers

PMID39958377
PMCPMC11810039

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.