Evidence map›Paper›PMID 39958262›Full record

ReviewBrain communications2025

Brainstem and cerebellar radiological findings in progressive supranuclear palsy.

Chloe Spiegel, Cassandra Marotta, Kelly Bertram, Lucy Vivash, Ian H Harding

Abstract readReview
In one paragraph

Review in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. A Brainstem Radiomics Framework to Distinguish Progressive Supranuclear Palsy from Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chloe SpiegelDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne 3004, Australia.ORCID https://orcid.org/0009-0002-4274-2785
Cassandra MarottaDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne 3004, Australia.ORCID https://orcid.org/0009-0008-8430-4824
Kelly BertramDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne 3004, Australia.
Lucy VivashDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne 3004, Australia.ORCID https://orcid.org/0000-0002-1182-0907
Ian H HardingDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne 3004, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Progressive supranuclear palsy is a sporadic neurodegenerative 4-repeat tauopathy associated with significant morbidity. Heterogeneity of symptom expression among this group is increasingly recognized, reflecting variable tau spread and neurodegeneration. Clinical manifestations consist of debilitating and rapidly progressive motor, oculomotor, speech, cognitive and affective impairments. Core pathological changes are noted with a predominance in the midbrain and basal ganglia; however, spread to the more caudal brainstem and cerebellar regions is reported at various stages. Accordingly, whilst midbrain atrophy is the best recognized supportive imaging finding, quantitative neuroimaging studies using MRI and PET approaches have revealed a wider profile of brain abnormalities in cohorts of individuals with progressive supranuclear palsy. This expanded neurobiological scope of disease may account for individual heterogeneity and may highlight additional biological markers that are relevant to diagnosing and tracking the illness. Additionally, there is increasing understanding of the diverse cognitive, affective and speech functions of the cerebellum, which may be implicated in progressive supranuclear palsy beyond current recognition. In this review, we undertake a systematic literature search and summary of

Indexed as

brainstemcerebellummagnetic resonance imagingpositron emission tomographyprogressive supranuclear palsy

Identifiers

PMID39958262
PMCPMC11829206

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.