ArticleBrain communications2025
Brain connectivity in individuals with migraine resets during the headache phase: a whole-brain connectivity study.
Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Review
- Early life stress induces brain-wide electrical network predisposition to migraine.The journal of headache and pain · 2026Article
- The MIND Study: Design, Feasibility, and Baseline Characteristics of a Smartphone-Based Migraine Cohort.medRxiv : the preprint server for health sciences · 2026Article
- Subtype-specific enhancement of implicit statistical learning in migraine: insights from BOLD signal variability.The journal of headache and pain · 2026Article
- Effects of electroacupuncture at Zusanli on pain-perception-related brain nuclei in KOA mice: a study on cortical and subcortical c-fos expression.Behavioral and brain functions : BBF · 2026Article
- Static and dynamic functional connectivity of the bilateral insula in patients with migraine without aura: a resting-state fMRI study.Frontiers in neurology · 2026Article
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4 authors.
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Abstract
Episodic migraine is reflected by cyclic changes in behavior and cortical processing. We aimed to identify how functional connectivity changes over the entire migraine cycle. By using longitudinal neuroimaging and a whole-brain connectivity analysis approach, we tested 12 episodic migraine patients across 82 functional MRI recordings during spontaneous migraine headaches with follow-up measurements over the pain-free interval without any external stimulation. We found that the functional connectivity linearly increased over the interictal interval. In the prodromal phase, we observed the strongest connections between the anterior agranular insula and the posterior orbitofrontal cortex with sensory, motor and cingulate areas. The strength of the connections dropped during the headache. Peak connectivity during the prodromal phase and its collapse during the headache can be regarded as a mechanism of normalizing cortical processing. We speculate about a malfunction at the molecular level in agranular frontal and insular regions, which needs to be addressed in subsequent studies.
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