ArticleTranslational lung cancer research2025
Efficacy of adjuvant tegafur-uracil (UFT) in early-stage non-small cell lung cancer with poor prognostic factors.
Article in Translational lung cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Efficacy of Tegafur-Uracil Maintenance Therapy in Non-Metastatic Head and Neck Squamous Cell Carcinoma: A Meta-Analysis With Trial Sequential Analysis.World journal of oncology · 2025Article
- Article
- Safety of Adjuvant Oral Uracil-Tegafur Therapy in Older Patients With Resected Non-small Cell Lung Cancer.Cancer diagnosis & prognosisArticle
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7 authors.
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Abstract
Background: Postoperative recurrence is a significant problem in patients with early-stage non-small cell lung cancer (NSCLC), with recurrence rates of 35% for stage IB and 50% for stage IIA. This study aimed to evaluate the efficacy of tegafur-uracil (UFT) as an adjuvant therapy in NSCLC patients with poor prognostic factors. Methods: A retrospective analysis was conducted of 330 patients with stage IB/IIA NSCLC who underwent lung resection between 2000 and 2019. Patients were divided into two groups based on the presence of poor prognostic factors (vascular, lymphatic, or pleural invasion or high pathological grade). Recurrence-free survival (RFS) and overall survival (OS) were compared between the UFT-treated and untreated groups using a Kaplan-Meier analysis. Results: Among these patients, 85.8% had poor prognostic factors. In patients with poor prognostic factors, the 5-year RFS rates in the UFT and non-UFT groups were 74.3% and 62.6%, respectively (P=0.048), and the 5-year OS was 85.6% and 62.4%, respectively (P<0.001). In patients without poor prognostic factors, UFT significantly extended OS (90.2% Conclusions: Postoperative adjuvant therapy with UFT significantly improved both RFS and OS in patients with stage IB/IIA NSCLC with poor prognostic factors. The administration of UFT should be considered in patients with high-risk early-stage NSCLC.
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