Evidence map›Paper›PMID 39958209›Full record

ArticleTranslational lung cancer research2025

Lingxiao Qiu, Tingcheng Li, Bin Qing, Cailin Zhao, Xinye Zhang, Satoshi Watanabe, Armida D'Incecco, Ninh M La-Beck, Tracy L Leong, Chuangye Wang and 6 more

Abstract read
In one paragraph

Article in Translational lung cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Lingxiao Qiu *Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing, China.ORCID https://orcid.org/0000-0002-1703-0797
Tingcheng Li *College of Mechanical and Electrical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, China.ORCID https://orcid.org/0000-0001-8304-8699
Bin QingDepartment of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing, China.
Cailin ZhaoDepartment of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing, China.
Xinye ZhangThoracic Surgery Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Satoshi WatanabeDepartment of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Armida D'InceccoMedical Oncology Unit, "G. Mazzini" Hospital of Teramo, Teramo, Italy.
Ninh M La-BeckDepartment of Immunotherapeutics and Biotechnology, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Abilene, TX, USA.
Tracy L LeongDepartment of Respiratory Medicine, Austin Hospital, Heidelberg, Victoria, Australia.
Chuangye WangDepartment of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing, China.
Jincheng LiuDepartment of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing, China.
Qi LiDepartment of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing, China.
Li BaiDepartment of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing, China.
Gang LiuDepartment of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing, China.
Xueping LiuDepartment of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing, China.
Zhi XuDepartment of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Lung adenocarcinoma (LUAD) is the predominant histological subtype of lung cancer. In the past decade, various targeted drugs have prolonged the survival of LUAD patients. Unfortunately, not all LUAD patients can benefit from the current target agents. Although the membrane spanning 4-domains A15 ( Methods: The pan-cancer RNA sequencing and clinical data of LUAD patients, originally comprising data from The Cancer Genome Atlas and Genotypic Tissue Expression, were acquired from University of California Santa Cruz XENA (UCSC XENA). Additionally, the GSE116959 and GSE130779 data sets were retrieved from the Gene Expression Omnibus database. The Differential Expression analysis of Sequencing data version 2 (DESeq2) package was used to identify the differentially expressed genes. The ClusteProfiler package was used to perform the Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and gene set enrichment analyses. An immune cell infiltration analysis was conducted using the gene set variation analysis (GSVA) package. The expression level of Results: Conclusions: Overall,

Indexed as

Gene Expression Omnibus (GEO)Genotypic Tissue Expression (GTEx)Lung adenocarcinoma (LUAD)membrane spanning 4-domains A15 (MS4A15)The Cancer Genome Atlas (TCGA)

Identifiers

PMID39958209
PMCPMC11826265

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.