Evidence map›Paper›PMID 39958137›Full record

ArticleCureus2025

Hemophagocytic Lymphohistiocytosis Secondary to Non-Hodgkin Lymphoma: A Case Report.

Joana Castro Vieira, Ricardo Madeira, Mafalda Maria Santos, João Vieira Afonso, Ana Cristina Teotónio

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Joana Castro VieiraInternal Medicine, Unidade Local de Saúde do Oeste - Hospital Distrital das Caldas da Rainha, Caldas da Rainha, PRT.
Ricardo MadeiraAnesthesiology, Unidade Local de Saúde da Região de Leiria, Leiria, PRT.
Mafalda Maria SantosInternal Medicine, Unidade Local de Saúde do Oeste - Hospital Distrital das Caldas da Rainha, Caldas da Rainha, PRT.
João Vieira AfonsoInternal Medicine, Unidade Local de Saúde do Oeste - Hospital Distrital das Caldas da Rainha, Caldas da Rainha, PRT.
Ana Cristina TeotónioInternal Medicine, Unidade Local de Saúde do Oeste - Hospital Distrital das Caldas da Rainha, Caldas da Rainha, PRT.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome characterized by uncontrolled immune activation, often associated with malignancy in adults. Early recognition and prompt initiation of treatment are crucial in managing this condition due to its rapid progression and poor prognosis. We report the case of a 75-year-old male with suspected lymphoproliferative disease who presented with clinical criteria compatible with HLH. Immediate treatment with dexamethasone led to rapid clinical improvement, and the patient was referred to hematology for continued management of the underlying disease. This case highlights the importance of constant clinical surveillance, early intervention, and the use of well-structured diagnostic tools in managing this syndrome in adults, where significant diagnostic and treatment challenges remain.

Indexed as

cytokine stormdexamethasonehlhhlh associated with malignancyhlh in adultshscorehyperinflammation

Identifiers

PMID39958137
PMCPMC11828383

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.