ArticleCureus2025
Comparison of Pre-dilution and Post-dilution Methods on Cytokine Clearance Using Polymethylmethacrylate (PMMA) Membrane Hemofilters in Continuous Hemodiafiltration.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Japan, the post-dilution method is preferred to maintain the dialysis efficiency of low molecular weight substances in continuous hemodiafiltration (CHDF). In contrast, the pre-dilution method is preferable to ensure a stable filter lifetime, especially for membranes with cytokine absorptive characteristics that are at high risk of membrane coagulation. However, the impact of the dilution method on the removal performance of adsorptive membranes for cytokines remains unclear. This study aimed to investigate the effect of different dilution methods on the adsorption clearance of cytokine on polymethylmethacrylate (PMMA) membranes by in vitro experiments. Bovine albumin, interleukin (IL)-6, and creatinine were added to phosphate-buffered saline to achieve final concentrations of 3.5 g/dL, 1000 pg/mL, and 10 mg/dL, respectively. The test solution was passed through the 1.8 m
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Registered trials
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