ReviewCureus2025
Asthma as a Modifiable Risk Factor for Dementia and Neurodegeneration: A Systematic Review.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Asthma and COPD Beyond the Airways: Exploring Neurocognitive Links Through NF-κB Subunits c-Rel and p65.International journal of molecular sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Asthma remains a significant health concern, with increasing incidence rates and a notable annual mortality rate. Although the pathophysiology of asthma and its impact on the respiratory system are well understood, leading to effective symptom control, the broader effects of chronic localized airway inflammation on the rest of the body remain less clear. One potential consequence of this persistent state is an elevated risk of developing dementia across various etiologies, including Alzheimer's disease (AD). This systematic review aims to elucidate the underlying mechanisms driving this association, with a particular focus on identifying neurodegeneration markers detectable through laboratory and imaging studies. Additionally, it examines the impact of asthma treatments on this potential risk, exploring their possible contributory role in the pathogenesis of dementia. Such insights should inform the development of personalized treatment strategies for asthma patients, aimed at preventing or delaying the onset of dementia. However, further research is necessary to understand the underlying mechanisms of the connection fully and crucial to integrate it with routine clinical practice.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.