ArticleCureus2025
Comparative Impact of Microsurgical Varicocelectomy Versus Observation on Infertility in Infertile Men With Subclinical Varicocele.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Is Varicocele Truly Unilateral? Contralateral Involvement and Bilateral Testicular Effects in Male Infertility: A Narrative Review.Journal of personalized medicine · 2026Review
- Why Varicoceles Recur: Missed Venous Anatomy and Contemporary Strategies for Salvage.Journal of clinical medicine · 2026Review
- Development of a predictive nomogram for microscopic inferior epigastric vein-internal spermatic vein surgery in male infertility with combined varicocele and nutcracker syndrome.American journal of translational research · 2025Article
- Male Reproductive Phenotype Heterogeneity in Varicocele: A Hypothesis-Generating Threshold-Resilience Framework and Research Agenda.Reproductive medicine and biologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe efficacy of varicocelectomy in treating infertility among men with ultrasonography-detected subclinical varicocele continues to be a topic of clinical uncertainty. This multicentric, prospective, non-randomized study aimed to evaluate the effect of microsurgical ligation of the internal spermatic vein in men with left subclinical varicocele and no other infertility causes. PATIENTS AND
methodsThe study included 34 infertile men diagnosed with subclinical left varicocele by color Doppler ultrasonography. After a shared decision-making process, the participants self-selected either microsurgical ligation (n = 18) or conservative management (n = 16). Baseline age, duration of infertility, reproductive hormone levels, and semen parameters were comparable across groups. The primary outcomes included changes in sperm concentration, progressive motility, and morphology over a nine-month follow-up period.
resultsAfter nine months, there were no statistically significant differences between the surgery and observation groups in sperm concentration or progressive motility. After adjusting for baseline values, sperm concentration increased by 3 × 10
conclusionAlthough this study's small sample size limits its broader generalizability, its findings provide limited evidence that microsurgical ligation may modestly improve sperm morphology in men with subclinical varicocele. Further research with larger, randomized cohorts is warranted to confirm these results and assess potential fertility outcomes.
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