ArticleCureus2025
Clear Cell Variant of Oral Squamous Cell Carcinoma: A Rare Case.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The clear cell variant of oral squamous cell carcinoma (CCSCC) is an uncommon aggressive lesion found in the oral cavity. Limited cases of CCSCC have been documented in the literature. This report discusses a 38-year-old female presenting with a non-healing ulcer in the right retromolar region, accompanied by pain and discomfort. Histopathological analysis revealed sheets and islands of severely dysplastic epithelial cells with clear cytoplasm and keratin pearls within the connective tissue, indicating a rare variant of oral squamous cell carcinoma. Various differential diagnoses were kept in mind, and a series of histopathological, histochemical, and immunohistochemical markers were carried out to confirm the origin of these clear cells. It was positive for cytokeratin 8, cytokeratin 18, and cytokeratin cocktail (AE1/AE3). It was negative for vimentin, S100, and HMB45. Thus, our final diagnosis was a CCSCC. This variant is seldom encountered. It often presents diagnostic challenges and is also an enigma to understanding its biological behavior.
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