ArticleFrontiers in cardiovascular medicine2025
Sex differences in cardiorespiratory control under hypoxia: the roles of oxygen desaturation and hypoxic exposure time.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Resting and Physical Activity Energy Expenditure Across an Altitudinal Gradient: An Adjusted Analysis.Oxygen (Basel, Switzerland) · 2026Article
- Article
- Acute Effect of Normobaric Hypoxia on Performance in Repeated Wingate Tests with Longer Recovery Periods and Neuromuscular Fatigue in Triathletes: Sex Differences.Journal of functional morphology and kinesiology · 2025Article
- Editorial: Updates on cardiovascular variability: underlying mechanisms and non-pharmacological therapeutic targets.Frontiers in cardiovascular medicine · 2025Article
- Functional/dissociative seizures as a neuroenergetic deficit syndrome: a brain economy failure hypothesis.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Males and females differ anatomically and functionally in cardiorespiratory regulation, with males tending to experience greater oxygen desaturation under hypoxia. Therefore, sex might moderate cardiorespiratory responses to acute hypoxia exposure. Accordingly, we hypothesized that sex differences in cardiovascular and ventilatory responses would be more pronounced with equal hypoxia duration (iso-time) but less pronounced at similar oxygen desaturation levels (iso-saturation). Methods: Twenty-two (12 females) healthy individuals were exposed to normoxia (10 min at FiO Results: At 10 min of hypoxia (iso-time), males desaturated more than females (interaction: Conclusion: Our data indicate that females counterbalance hypoxia mainly by systemic circulatory adjustments, while males use both, circulatory and ventilatory adjustments.
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