ArticleRSC advances2025
Revolutionary NIR-activated silicon nanoparticles: precision-controlled release and targeted 3D cancer cell destruction.
Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In cancer therapy, controlled and targeted drug release systems are essential to maximize therapeutic outcomes while minimizing adverse effects. This study introduces an innovative mesoporous silicon nanoparticle (MSN) platform, functionalized with the natural anticancer agent dieckol (Di) and designed for precise drug delivery activated by near-infrared (NIR) irradiation. By embedding Di and grafting fluorescent organic conjugates onto the MSN surface, this innovative nanocarrier demonstrates exceptional sensitivity to NIR stimuli and potent chemo-photothermal effects. Notably, drug release remains stable across different pH conditions (7.4, 6.5, and 5.5), ensuring consistent therapeutic delivery. However, upon NIR exposure, the release can be selectively accelerated, enabling precise, real-time, and on-demand drug release control for enhanced treatment efficacy. Cytotoxicity tests revealed that IPSi-Dox-Di-DQA nanoparticles exhibited potent dose-dependent inhibition of cancer cell growth (SH-SY5Y and B16-F10), while sparing healthy cells (HEK-293), highlighting their specificity. Furthermore, advanced 3D cell viability assays mimic the complexities of
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Registered trials
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