Evidence map›Paper›PMID 39957753›Full record

ArticleLiver research (Beijing, China)2024

Leukocyte cell-derived chemotaxin 2 (LECT2) regulates liver ischemia-reperfusion injury.

Meng-Qi Dong, Yuan Xie, Zhi-Liang Tang, Xue-Wen Zhao, Fu-Zhen Lin, Guang-Yu Zhang, Zhi-Hao Huang, Zhi-Min Liu, Yuan Lin, Feng-Yong Liu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Liver research (Beijing, China), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Meng-Qi DongState Key Laboratory of Organ Failure Research, Department of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Yuan XieDepartment of Hepato-Biliary-Pancreatic and Hernia Surgery, The First People's Hospital of Zhaoqing, Zhaoqing, Guangdong, China.
Zhi-Liang TangDepartment of Hepato-Biliary-Pancreatic and Hernia Surgery, The First People's Hospital of Zhaoqing, Zhaoqing, Guangdong, China.
Xue-Wen ZhaoDepartment of Hepato-Biliary-Pancreatic and Hernia Surgery, The First People's Hospital of Zhaoqing, Zhaoqing, Guangdong, China.
Fu-Zhen LinDepartment of Hepato-Biliary-Pancreatic and Hernia Surgery, The First People's Hospital of Zhaoqing, Zhaoqing, Guangdong, China.
Guang-Yu ZhangDepartment of Hepato-Biliary-Pancreatic and Hernia Surgery, The First People's Hospital of Zhaoqing, Zhaoqing, Guangdong, China.
Zhi-Hao HuangState Key Laboratory of Organ Failure Research, Department of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Zhi-Min LiuState Key Laboratory of Organ Failure Research, Department of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Yuan LinState Key Laboratory of Organ Failure Research, Department of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Feng-Yong LiuDepartment of Interventional Radiology, Senior Department of Oncology, Fifth Medical Center of PLA General Hospital, Beijing, China.
Wei-Jie ZhouState Key Laboratory of Organ Failure Research, Department of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and aim: Hepatic ischemia-reperfusion injury (IRI) is a significant challenge in liver transplantation, trauma, hypovolemic shock, and hepatectomy, with limited effective interventions available. This study aimed to investigate the role of leukocyte cell-derived chemotaxin 2 (LECT2) in hepatic IRI and assess the therapeutic potential of Lect2-short hairpin RNA (shRNA) delivered through adeno-associated virus (AAV) vectors. Materials and methods: This study analyzed human liver and serum samples from five patients undergoing the Pringle maneuver. Results: Serum and liver LECT2 levels were elevated during hepatic IRI. Serum LECT2 protein and mRNA levels increased post reperfusion. Conclusions: Elevated LECT2 levels during hepatic IRI increased liver damage. Genetic knockout or shRNA-mediated knockdown of

Indexed as

Adeno-associated virus (AAV)Hepatic ischemia–reperfusion injury (IRI)Leukocyte cell-derived chemotaxin 2 (LECT2)

Identifiers

PMID39957753
PMCPMC11771270

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.