Evidence map›Paper›PMID 39957696›Full record

ArticleCurrent cancer drug targets2025

7-Dehydrocholesterol Reductase Activates the Hedgehog Pathway by Regulating Cholesterol to Promote the Development of Triple-Negative Breast Cancer.

Shuang Qiu, Yu Sun, Yuanyuan Liu, Jinyu Yang, Xin Chen, Di Wu, Li Li, Jianwei Sun

Abstract read
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Article in Current cancer drug targets, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shuang QiuDepartment of Breast Thyroid Surgery, First People's Hospital of Yunnan Province, Kunming University of Science and Technology, Kunming 650032, Yunnan, China.
Yu SunDepartment of Breast Thyroid Surgery, First People's Hospital of Yunnan Province, Kunming University of Science and Technology, Kunming 650032, Yunnan, China.
Yuanyuan LiuDepartment of Breast Thyroid Surgery, First People's Hospital of Yunnan Province, Kunming University of Science and Technology, Kunming 650032, Yunnan, China.
Jinyu YangDepartment of Breast Thyroid Surgery, First People's Hospital of Yunnan Province, Kunming University of Science and Technology, Kunming 650032, Yunnan, China.
Xin ChenDepartment of Breast Thyroid Surgery, First People's Hospital of Yunnan Province, Kunming University of Science and Technology, Kunming 650032, Yunnan, China.
Di WuDepartment of Breast Thyroid Surgery, First People's Hospital of Yunnan Province, Kunming University of Science and Technology, Kunming 650032, Yunnan, China.
Li LiDepartment of Breast Thyroid Surgery, First People's Hospital of Yunnan Province, Kunming University of Science and Technology, Kunming 650032, Yunnan, China.
Jianwei SunDepartment of Breast Thyroid Surgery, First People's Hospital of Yunnan Province, Kunming University of Science and Technology, Kunming 650032, Yunnan, China.

Funding

Joint Special Program of Basic Research of Yunnan Provincial Department of Science and Technology-Kunming Medical University 202201AY070001-262Wu Jieping Medical Foundation 320.6750.2022-19-27
6 · The paper itself

Abstract

backgroundCholesterol has been shown to be a potential risk factor for the occurrence and progression of breast cancer. This study aimed to investigate the regulation of DHCR7 in cholesterol synthesis and its role in Hedgehog (Hh) signaling pathway activation, as well as its impact on the progression of triple-negative breast cancer (TNBC).

methodsWe analyzed the gene expression data from the GSE76275 data set by bioinformatics analysis to determine the expression of cholesterol-related genes in TNBC. In the TNBC cell lines, including BT-549 and MDA-MB-231, RNA interference gene knockout was used to evaluate the functional impact of DHCR7. In addition, the SMO mutant (SMO

resultsDHCR7 expression was significantly elevated in TNBC tissues and cell lines, enhancing the Hh pathway activity through cholesterol modulation. Knocking down DHCR7 and the SMO

conclusionDHCR7 activates the Hedgehog pathway by regulating cholesterol to promote the development of TNBC. These findings provide insights into the regulatory roles of DHCR7 in cholesterol-related pathways and Hh signaling in TNBC cells, offering potential therapeutic targets for TNBC treatment.

Indexed as

CholesterolHedgehog ProteinsOxidoreductases Acting on CH-CH Group DonorsTriple Negative Breast NeoplasmsCell Line, TumorCell MovementCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansSignal TransductionSmoothened Receptor7-dehydrocholesterol reductaseCholesterolHedgehog ProteinsOxidoreductases Acting on CH-CH Group DonorsSmoothened ReceptorSMO protein, humancholesterolDHCR7Hedgehog signaling pathwaySMOTriple-negative breast cancerV329F.

Identifiers

PMID39957696

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.